Dipeptidilna peptidaza I

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(Preusmjereno sa Katepsin C)
Dipeptidilna peptidaza I
1k3b.jpg
Heterododekamer katepsina C (čovjek)
Identifikatori
EC broj 3.4.14.1
CAS broj 9032-68-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Dipeptidilna peptidaza I (EC 3.4.14.1, katepsin C, dipeptidilna aminopeptidaza I, dipeptidilna transferaza, katepsin C, dipeptidilna transferaza, dipeptidna arilamidaza I, DAP I) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje N-terminalnog dipeptida, Xaa-Yaa-Zaa-, izuzev kad je Xaa: Arg ili Lys, ili je Yaa: Zaa ili Pro

Ovaj enzim je zavistan od jona Cl-.

Reference[uredi - уреди | uredi izvor]

  1. Planta, R.J., Gorter, J. and Gruber, M. (1964). "The catalytic properties of cathepsin C". Biochim. Biophys. Acta 89: 511–519. PMID 14209333. 
  2. Metrione, R.M., Neves, A.G. and Fruton, J.S. (1966). "Purification and properties of dipeptidyl transferase (cathepsin C)". Biochemistry 5: 1597–1604. PMID 5961281. 
  3. McDonald, J.K., Zeitman, B.B., Reilly, T.J. and Ellis, S. (1969). "New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I) including the degradation of β-corticotropin and other peptide hormones". J. Biol. Chem. 244: 2693–2709. PMID 4306035. 
  4. McDonald, J.K. and Schwabe, C. (1977). "Intracellular exopeptidases". u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391. 

Literatura[uredi - уреди | uredi izvor]

  • McDonald, J.K. and Schwabe, C. (1977). "Intracellular exopeptidases". u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391. 

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