Katepsin B
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| Katepsin B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.22.1 | ||||||||
| CAS broj | 9047-22-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Katepsin B (EC 3.4.22.1, katepsin B1, katepsin II) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičšću za peptidne veze. Preferentno dolazi do razlaganja -Arg-Arg- veza u malim molekulskim supstratima (po čeme se razlikuje od katepsina L).
Ovaj intraćelijski (lizozomalni) enzim pripada peptidaznoj familiji C1 (papainskoj familiji)
Reference[uredi | uredi kod]
- ↑ Bond, J.S. and Barrett, A.J. (1980). „Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase”. Biochem. J. 189: 17-25. PMID 7458901.
- ↑ Barrett, A.J. and Kirschke, H. (1981). „Cathepsin B, cathepsin H and cathepsin L”. Methods Enzymol. 80: 535-561. PMID 7043200.
- ↑ Polgár, L. and Csoma, C. (1987). „Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B”. J. Biol. Chem. 262: 14448-14453. PMID 3312190.
- ↑ Barrett, A.J., Buttle, D.J. and Mason, R.W. (1988). „Lysosomal cysteine proteinases”. ISI Atlas of Science. Biochemistry 1: 256-260.
- ↑ Kirschke, H., Wikstrom, P. and Shaw, E. (1988). „Active center differences between cathepsins L and B: the S1 binding region”. FEBS Lett. 228: 128-130. PMID 3342870.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.