Kaspaza-4

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Kaspaza-4
Identifikatori
EC broj 3.4.22.57
CAS broj 182762-08-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Kaspaza-4 (EC 3.4.22.57, ICErel-II, Ich-2, transkript X, TX, TX proteaza, kaspaza 4, CASP-4) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Tyr-Val-Ala-Asp-, ali se takođe razlaže Asp-Glu-Val-Asp-

Ovaj enzim pripada familiji inflamatornih kaspaza, koja takođe obuhvata kaspazu-1 (EC 3.4.22.36) i kaspazu-5 (EC 3.4.22.58) kod ljudi i kaspazu-11 (EC 3.4.22.64), kaspazu-12, kaspazu-13 i kaspazu-14 kod miševa.

Reference[uredi - уреди | uredi izvor]

  1. Faucheu, C., Diu, A., Chan, A.W., Blanchet, A.M., Miossec, C., Hervé, F., Collard-Dutilleul, V., Gu, Y., Aldape, R.A., Lippke, J.A., Rocher, C., Su, M.S.-S., Livingston, D.J., Hercend, T. and Lalanne, J.-L. (1995). "A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells". EMBO J. 14: 1914–1922. PMID 7743998. 
  2. Kamens, J., Paskind, M., Hugunin, M., Talanian, R.V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C.G., Li, P., Mankovich, J.A., Terranova, M. and Ghayur, T. (1995). "Identification and characterization of ICH-2, a novel member of the interleukin-1β-converting enzyme family of cysteine proteases". J. Biol. Chem. 270: 15250–15256. PMID 7797510. 
  3. Kamada, S., Funahashi, Y. and Tsujimoto, Y. (1997). "Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases". Cell Death Differ. 4: 473–478. PMID 16465268. 
  4. Fassy, F., Krebs, O., Rey, H., Komara, B., Gillard, C., Capdevila, C., Yea, C., Faucheu, C., Blanchet, A.M., Miossec, C. and Diu-Hercend, A. (1998). "Enzymatic activity of two caspases related to interleukin-1β-converting enzyme". Eur. J. Biochem. 253: 76–83. PMID 9578463. 
  5. Martinon, F. and Tschopp, J. (2004). "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases". Cell 117: 561–574. PMID 15163405. 
  6. Chang, H.Y. and Yang, X. (2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiol. Mol. Biol. Rev. 64: 821–846. PMID 11104820. 

Literatura[uredi - уреди | uredi izvor]

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