Kaspaza-11
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| Kaspaza-11 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.64 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kaspaza-11 (EC 3.4.22.64, CASP-11) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence (Ile/Leu/Val/Phe)-Gly-His-Asp-
Ovaj murinski enzim je deo familije inflamatornih kaspaza, u koji se takođe ubrajaju kaspaza-1 (EC 3.4.22.36), kaspaza-4 (EC 3.4.22.57) i kaspaza-5 (EC 3.4.22.58) kod ljudi i kaspaza-12, kaspaza-13 i kaspaza-14 kod miševa.
Reference[uredi | uredi kod]
- ↑ Kang, S.J., Wang, S., Hara, H., Peterson, E.P., Namura, S., Amin-Hanjani, S., Huang, Z., Srinivasan, A., Tomaselli, K.J., Thornberry, N.A., Moskowitz, M.A. and Yuan, J. (2000). „Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions”. J. Cell. Biol. 149: 613-622. PMID 10791975.
- ↑ Hur, J., Kim, S.Y., Kim, H., Cha, S., Lee, M.S. and Suk, K. (2001). „Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway”. FEBS Lett. 507: 157-162. PMID 11684090.
- ↑ Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E. and Yuan, J. (1998). „Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE”. Cell 92: 501-509. PMID 9491891.
- ↑ Endo, M., Mori, M., Akira, S. and Gotoh, T. (2006). „C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation”. J. Immunol. 176: 6245-6253. PMID 16670335.
- ↑ Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.