Kaspaza-1

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Kaspaza-1
Protein CASP1 PDB 1bmq.png
Identifikatori
EC broj 3.4.22.36
CAS broj 122191-40-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Kaspaza-1 (EC 3.4.22.36, interleukin 1beta-konvertujući enzim, proteaza VII, proteaza A, interleukin 1beta prekurzorna proteinaza, interleukin 1 konvertujući enzim, interleukin 1beta-konvertujuća endopeptidaza, interleukin-1beta konvertaza, interleukin-1beta konvertujući enzim, interleukin-1beta prekurzorna proteinaza, prointerleukin 1beta proteaza, prekurzor interleukin-1beta konvertujući enzim, pro-interleukinska 1beta proteinaza, ICE) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina, pri čemu je neophodno da je Asp ostatak u pozicija P1. Preferentne sekvenca razlaganja je Tyr-Val-Ala-Asp-

Ovaj enzim se javlja u monocitima sisara.

Reference[uredi - уреди | uredi izvor]

  1. Howard, A., Kostura, M.J., Thornberry, N., Ding, G.J.., Limjuco, G., Weidner, J., Salley, J.P., Hogquist, K.A., Chaplin, D.D., Mumford, R.A., Schmidt, J.A. and Tocci, M.J. (1991). "IL-1 converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDa IL-1α". J. Immunol. 147: 2964–2969. PMID 1919001. 
  2. Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J., Elliston, K.O., Ayala, J.M., Casano, F (1992). "J., Chin, J., Ding, G.J.-F., Egger, L.A., Gaffney, E.P., Limjuco, G., Palyha, O.C., Raju, S.M., Rolando, A.M., Salley, J.P., Yamin, T.-T. and Tocci, M.J. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes". Nature 356: 768–774. PMID 1574116. 
  3. Thornberry, N.A. (1994). "Interleukin-1β converting enzyme". Methods Enzymol. 244: 615–631. PMID 7845238. 
  4. Alnemri, E.S., Livingston, D.J., Nicholson, D.W., Salvesen, G., Thornberry, N.A., Wong, W.W. and Yuan, J.Y. (1996). "Human ICE/CED-3 protease nomenclature". Cell 87: 171–171. PMID 8861900. 
  5. Margolin, N., Raybuck, S.A., Wilson, K.P., Chen, W.Y., Fox, T., Gu, Y. and Livingston, D.J. (1997). "Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases". J. Biol. Chem. 272: 7223–7228. PMID 9054418. 
  6. Martinon, F. and Tschopp, J. (2004). "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases". Cell 117: 561–574. PMID 15163405. 
  7. Chang, H.Y. and Yang, X. (2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiol. Mol. Biol. Rev. 64: 821–846. PMID 11104820. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]