Karboksibiotinska dekarboksilaza
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| Karboksibiotinska dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.99.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Karboksibiotinska dekarboksilaza (EC 4.3.99.2, MadB, karboksibiotin proteinska dekarboksilaza) je enzim sa sistematskim imenom karboksibiotinil-(protein) karboksi-lijaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- karboksibiotinil-[protein] + n Na+in + H+out CO2 + biotinil-[protein] + n Na+out (n = 1--2)
Ovaj integralni membranski protein MadB iz anaerobne bakterije Malonomonas rubra je komponenta multienzimskog kompleks EC 4.1.1.89, biotin-zavisne malonatne dekarboksilaze.
Reference[uredi | uredi kod]
- ↑ Berg, M., Hilbi, H. and Dimroth, P. (1997). „Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function”. Eur. J. Biochem. 245: 103-115. PMID 9128730.
- ↑ Dimroth, P. and Hilbi, H. (1997). „Enzymic and genetic basis for bacterial growth on malonate”. Mol. Microbiol. 25: 3-10. PMID 11902724.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.