Karbamoil-fosfatna sintaza (glutamin-hidrolizujuća)

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Karbamoil-fosfatna sintaza (glutamin-hidrolizujuća)
Identifikatori
EC broj 6.3.5.5
CAS broj 37233-48-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Karbamoil-fosfatna sintaza (glutamin-hidrolizujuća) (EC 6.3.5.5, karbamoil-fosfatna sintetaza (glutaminska hidroliza), karbamil fosfatna sintetaza (glutamin), karbamoilfosfatna sintetaza II, glutamin-zavisna karbamil fosfatna sintetaza, karbamoil fosfatna sintetaza, CPS, ugljen-dioksid:L-glutamin amido-ligaza (formira ADP, karbamatna fosforilacija)) je enzim sa sistematskim imenom vodonik-karbonat:L-glutamin amido-ligaza (formira ADP, karbamatna fosforilacija).[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 ATP + L-glutamin + HCO3- + H2O 2 ADP + fosfat + L-glutamat + karbamoil fosfat (sveukupna reakcija)
(1a) L-glutamin + H2O L-glutamat + NH3
(1b) 2 ATP + HCO3- + NH3 2 ADP + fosfat + karbamoil fosfat

Produkt karbamoil fosfat je intermedijer u biosintezi arginina i pirimidinskih nukleotida.

Reference[uredi - уреди | uredi izvor]

  1. Anderson, P.M. and Meister, A. (1965). "Evidence for an activated form of carbon dioxide in the reaction catalysed by Escherichia coli carbamyl phosphate synthetase". Biochemistry 4: 2803–2809. PMID 5326356. 
  2. Kalman, S.M., Duffield, P.H. and Brzozowski, T. (1966). "Purification and properties of a bacterial carbamyl phosphate synthetase". J. Biol. Chem. 241: 1871–1877. PMID 5329589. 
  3. Yip, M.C.M. and Knox, W.E. (1970). "Glutamine-dependent carbamyl phosphate synthetase. Properties and distribution in normal and neoplastic rat tissues". J. Biol. Chem. 245: 2199–2204. PMID 5442268. 
  4. Stapleton, M.A., Javid-Majd, F., Harmon, M.F., Hanks, B.A., Grahmann, J.L., Mullins, L.S. and Raushel, F.M. (1996). "Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase". Biochemistry 35: 14352–14361. PMID 8916922. 
  5. Holden, H.M., Thoden, J.B. and Raushel, F.M. (1998). "Carbamoyl phosphate synthetase: a tunnel runs through it". Curr. Opin. Struct. Biol. 8: 679–685. PMID 9914247. 
  6. Raushel, F.M., Thoden, J.B., Reinhart, G.D. and Holden, H.M. (1998). "Carbamoyl phosphate synthetase: a crooked path from substrates to products". Curr. Opin. Chem. Biol. 2: 624–632. PMID 9818189. 
  7. Raushel, F.M., Thoden, J.B. and Holden, H.M. (1999). "The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia". Biochemistry 38: 7891–7899. PMID 10387030. 
  8. Thoden, J.B., Huang, X., Raushel, F.M. and Holden, H.M. (2002). "Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia". J. Biol. Chem. 277: 39722–39727. PMID 12130656. 

Literatura[uredi - уреди | uredi izvor]

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