Kanakinumab
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| Klinički podaci | |
|---|---|
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 914613-48-2 |
| ATC kod | L04AC08 |
| DrugBank | DB06168 |
| ChEMBL[1] | CHEMBL1201834 
|
| Hemijski podaci | |
| Formula | C6452H9958N1722O2010S42 |
| Mol. masa | 145.2 kDa |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 26 dana |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Subkutano |
Kanakinumab (INN, Ilaris, ACZ885)[2] je ljudsko monoklonalno antitelo koje prepoznaje interleukin-1 beta, i ne vezuje se za druge članove interleukin-1 familije.[3][4][5][6][7][8]
Reference[uredi | uredi kod]
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Dhimolea, Eugen (2010). „Canakinumab”. MAbs 2 (1): 3–13. DOI:10.4161/mabs.2.1.10328. PMC 2828573. PMID 20065636.
- ↑ Lachmann, HJ; Kone-Paut I, Kuemmerle-Deschner JB et al. (2009-06-04). „Use of canakinumab in the cryopyrin-associated periodic syndrome”. New Engl J Med 360 (23): 2416–25. DOI:10.1056/NEJMoa0810787. PMID 19494217.
- ↑ Church LD, McDermott MF: Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr Opin Mol Ther. 2009 Feb;11(1):81-9. PMID 19169963
- ↑ IMGT Link:http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=8836 Arhivirano 2008-12-07 na Wayback Machine-u
- ↑ Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, Leslie KS, Hachulla E, Quartier P, Gitton X, Widmer A, Patel N, Hawkins PN: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009 Jun 4;360(23):2416-25. PMID 19494217
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
Literatura[uredi | uredi kod]
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
