Kalpain-2
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| Kalpain-2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.53 | ||||||||
| CAS broj | 702693-80-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kalpain-2 (EC 3.4.22.53, kalcijumom aktivirana neutralna proteaza II, m-kalpain, mili-kalpain) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endopeptidazno dejstvo sa širokom specifičnošću
Ovaj enzim pripada familiji C2 peptidaza.
Reference[uredi | uredi kod]
- ↑ Strobl, S., Fernandez-Catalan, C., Braun, M., Huber, R., Masumoto, H., Nakagawa, K., Irie, A., Sorimachi, H., Bourenkow, G., Bartunik, H., Suzuki, K. and Bode, W. (2000). „The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium”. Proc. Natl. Acad. Sci. USA 97: 588-592. PMID 10639123.
- ↑ Dutt, P., Spriggs, C.N., Davies, P.L., Jia, Z. and Elce, J.S. (2002). „Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain”. Biochem. J. 367: 263-269. PMID 12014988.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.