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Inzulizin (EC, insulinaza, insulin-degradirajući enzim, insulinska proteaza, insulinska proteinaza, insulin-degradirajuća neutralna proteinaza, insulin-specifična proteaza, insulin-glukagonska proteaza, metaloinsulinaza, IDE) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Degradacija insulina, glukagona i drugih polipeptida. Nije aktivan na drugim proteinima

Ovaj citosolni enzim je prisutan kod sisara i voćne mušice, Drosophila melanogaster.

Reference[uredi - уреди | uredi izvor]

  1. Duckworth, W.C. (1988). "Insulin degradation: mechanisms, products, and significance". Endocrine Rev. 9: 319–345. PMID 3061785. 
  2. Affholter, J.A., Hsieh, C.-L., Francke, U. and Roth, R.A. (1990). "Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes". Mol. Endocrinol. 4: 1125–1135. PMID 2293021. 
  3. Duckworth, W.C., Hamel, F.G., Bennett, R., Ryan, M.P. and Roth, R.A. (1990). "Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin". J. Biol. Chem. 265: 2984–2987. PMID 1689296. 
  4. Kuo, W.-L., Gehm, B.D. and Rosner, M.R. (1990). "Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme". Mol. Endocrinol. 4: 1580–1591. PMID 2126597. 
  5. Ding, L., Becker, A.B., Suzuki, A. and Roth, R.A. (1992). "Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III". J. Biol. Chem. 267: 2414–2420. PMID 1733942. 

Literatura[uredi - уреди | uredi izvor]

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