Izvorni kod stranice Interleukin 17A

{{PBB|geneid=3605}}
'''Interleukin 17A''' je [[protein]] koji je kod ljudi kodiran ''IL17A'' [[gen]]om.<ref name="pmid8390535">{{cite journal | author = Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P | title = CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene | journal = J Immunol | volume = 150 | issue = 12 | pages = 5445–56 | year = 1993 | month = Jul | pmid = 8390535 | pmc =  | doi =}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IL17A interleukin 17A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3605| accessdate = }}</ref><ref>{{MireSluisCytokines}}</ref>

{{PBB_Summary
| section_title = 
| summary_text = [[Protein]] kodiran ovim genom je proinflamatorni citokin proizveden aktiviranim [[T ćelija]]ma.<ref name="KubyImmunology6th">{{KubyImmunology6th}}</ref> Ovaj citokin reguliše aktivnosti [[NF-kapaB]] i mitogen aktiviranih [[protein]] kinaza. Ovaj citokin može da stimuliše izražavanje [[Interleukin|IL-6]] i [[ciklooksigenaza-2|ciklooksigenaze-2]] ([[PTGS2]]/[[COX-2]]), kao i da pojača produkciju [[Azot-monoksid]]a (NO). Visoki nivoi ovog citokina su asocirani sa nekoliko hroničnih inflamatornih oboljenja uključujući [[reumatoidni artritis]], [[psorijaza|psorijazu]] i [[multipla skleroza|multiplu sklerozu]].<ref name="entrez" />
}}

== Povezano ==
* [[Interleukin 17]]

== Reference ==
{{reflist|2}}

== Literatura ==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Gaffen SL |title=Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis. |journal=Arthritis Res. Ther. |volume=6 |issue= 6 |pages= 240–7 |year= 2005 |pmid= 15535837 |doi= 10.1186/ar1444  | pmc=1064872 }}
*{{cite journal  | author=Lubberts E, Koenders MI, van den Berg WB |title=The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. |journal=Arthritis Res. Ther. |volume=7 |issue= 1 |pages= 29–37 |year= 2006 |pmid= 15642151 |doi= 10.1186/ar1478  | pmc=1064899 }}
*{{cite journal  | author=Yao Z, Painter SL, Fanslow WC, ''et al.'' |title=Human IL-17: a novel cytokine derived from T cells. |journal=J. Immunol. |volume=155 |issue= 12 |pages= 5483–6 |year= 1996 |pmid= 7499828 |doi=}}
*{{cite journal  | author=Fossiez F, Djossou O, Chomarat P, ''et al.'' |title=T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. | url=https://archive.org/details/sim_journal-of-experimental-medicine_1996-06_183_6/page/2593 |journal=J. Exp. Med. |volume=183 |issue= 6 |pages= 2593–603 |year= 1996 |pmid= 8676080 |doi=10.1084/jem.183.6.2593  | pmc=2192621}}
*{{cite journal  | author=Yao Z, Spriggs MK, Derry JM, ''et al.'' |title=Molecular characterization of the human interleukin (IL)-17 receptor. |journal=Cytokine |volume=9 |issue= 11 |pages= 794–800 |year= 1998 |pmid= 9367539 |doi=10.1006/cyto.1997.0240}}
*{{cite journal  | author=Murphy KP, Gagne P, Pazmany C, Moody MD |title=Expression of human interleukin-17 in Pichia pastoris: purification and characterization. |journal=Protein Expr. Purif. |volume=12 |issue= 2 |pages= 208–14 |year= 1998 |pmid= 9518462 |doi= 10.1006/prep.1997.0832 }}
*{{cite journal  | author=Teunissen MB, Koomen CW, de Waal Malefyt R, ''et al.'' |title=Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. | url=https://archive.org/details/sim_journal-of-investigative-dermatology_1998-10_111_4/page/645 |journal=J. Invest. Dermatol. |volume=111 |issue= 4 |pages= 645–9 |year= 1998 |pmid= 9764847 |doi= 10.1046/j.1523-1747.1998.00347.x }}
*{{cite journal  | author=Shalom-Barak T, Quach J, Lotz M |title=Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27467–73 |year= 1998 |pmid= 9765276 |doi=10.1074/jbc.273.42.27467}}
*{{cite journal  | author=Shin HC, Benbernou N, Fekkar H, ''et al.'' |title=Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. |journal=Cytokine |volume=10 |issue= 11 |pages= 841–50 |year= 1999 |pmid= 9878122 |doi= 10.1006/cyto.1998.0375 }}
*{{cite journal  | author=Laan M, Cui ZH, Hoshino H, ''et al.'' |title=Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. |journal=J. Immunol. |volume=162 |issue= 4 |pages= 2347–52 |year= 1999 |pmid= 9973514 |doi=}}
*{{cite journal  | author=Kotake S, Udagawa N, Takahashi N, ''et al.'' |title=IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. | url=https://archive.org/details/sim_journal-of-clinical-investigation_1999-05_103_9/page/1345 |journal=J. Clin. Invest. |volume=103 |issue= 9 |pages= 1345–52 |year= 1999 |pmid= 10225978 |doi=10.1172/JCI5703  | pmc=408356}}
*{{cite journal  | author=Shin HC, Benbernou N, Esnault S, Guenounou M |title=Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. |journal=Cytokine |volume=11 |issue= 4 |pages= 257–66 |year= 1999 |pmid= 10328864 |doi= 10.1006/cyto.1998.0433 }}
*{{cite journal  | author=Andoh A, Takaya H, Makino J, ''et al.'' |title=Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells. |journal=Clin. Exp. Immunol. |volume=125 |issue= 1 |pages= 56–63 |year= 2001 |pmid= 11472426 |doi=10.1046/j.1365-2249.2001.01588.x  | pmc=1906093}}
*{{cite journal  | author=Laan M, Palmberg L, Larsson K, Lindén A |title=Free, soluble interleukin-17 protein during severe inflammation in human airways. |journal=Eur. Respir. J. |volume=19 |issue= 3 |pages= 534–7 |year= 2002 |pmid= 11936535 |doi=10.1183/09031936.02.00280902}}
*{{cite journal  | author=Andoh A, Fujino S, Bamba S, ''et al.'' |title=IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 1683–7 |year= 2002 |pmid= 12165487 |doi=}}
*{{cite journal  | author=Andoh A, Shimada M, Bamba S, ''et al.'' |title=Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 69–74 |year= 2002 |pmid= 12183057 |doi=10.1016/S0167-4889(02)00250-1}}
*{{cite journal  | author=Hsieh HG, Loong CC, Lin CY |title=Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells. |journal=Cytokine |volume=19 |issue= 4 |pages= 159–74 |year= 2003 |pmid= 12297109 |doi=10.1006/cyto.2002.1952}}
*{{cite journal  | author=Aggarwal S, Ghilardi N, Xie MH, ''et al.'' |title=Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1910–4 |year= 2003 |pmid= 12417590 |doi= 10.1074/jbc.M207577200 }}
*{{cite journal  | author=Maertzdorf J, Osterhaus AD, Verjans GM |title=IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. |journal=J. Immunol. |volume=169 |issue= 10 |pages= 5897–903 |year= 2003 |pmid= 12421973 |doi=}}
}}
{{refend}}

== Spoljašnje veze ==
* {{MeshName|Interleukin-17}}
{{Commons category-inline|Cytokines}}
{{-}}
{{Interleukini}}
{{Citokini}}

[[Kategorija:Interleukini]]
[[Kategorija:Imunologija]]