Indol-3-glicerol-fosfatna sintaza
(Preusmjereno sa stranice Indol-3-glicerol-fosfat sintaza)
| Indol-3-glicerol-fosfatna sintaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 4.1.1.48 | ||||||||
| CAS broj | 9031-60-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Indol-3-glicerol-fosfatna sintaza (EC 4.1.1.48, indolglicerol fosfatna sintetaza, indolglicerol fosfatna sintaza, indol-3-glicerofosfatna sintaza, 1-(2-karboksifenilamino)-1-dezoksi-D-ribuloza-5-fosfat karboksi-lijaza (ciklizacija)) je enzim sa sistematskim imenom 1-(2-karboksifenilamino)-1-dezoksi-D-ribuloza-5-fosfat karboksilijaza (ciklizacija; formira 1-C-(indol-3-il)glicerol-3-fosfat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-(2-karboksifenilamino)-1-dezoksi-D-ribuloza 5-fosfat 1-C-(indol-3-il)glicerol 3-fosfat + CO2 +H2O
U pojedinim organizmima ovaj enzim je deo multifunkcionalnog proteina.
Reference[uredi | uredi kod]
- ↑ Creighton, T.E. and Yanofsky, C. (1966). „Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon”. J. Biol. Chem. 241: 4616-4624. PMID 5332729.
- ↑ Creighton, T.E. and Yanofsky, C. (1970). „Chorismate to tryptophan (Escherichia coli) - anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase”. Methods Enzymol. 17A: 365-380.
- ↑ Hütter, R., Niederberger, P. and DeMoss, J.A. (1986). „Tryptophan synthetic genes in eukaryotic microorganisms”. Annu. Rev. Microbiol. 40: 55-77. PMID 3535653.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.