IgA-specifična serinska endopeptidaza
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| IgA-specifična serinska endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.72 | ||||||||
| CAS broj | 55127-02-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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IgA-specifična serinska endopeptidaza (EC 3.4.21.72, IgA proteaza, IgA proteinaza, IgA-specifična proteinaza, imunoglobulinska A proteaza, imunoglobulinska A proteinaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje molekula imunoglobulina A na pojedinim Pro- vezan u regionu šarke. Mali molekuli nisu supstrati
Varijante enzima iz različitih vrsta Gram-negativnih bakterija (Neisseria gonorrhoeae i Haemophilus influenzae) se u izvesnoj meri razlikuju u pogledu specifičnosti.
Reference[uredi | uredi kod]
- ↑ Plaut, A.G. (1983). „The IgA1 proteases of pathogenic bacteria”. Annu. Rev. Microbiol. 37: 603-622. PMID 6416146.
- ↑ Bachovchin, W.W., Plaut, A.G., Flentke, G.R., Lynch, M. and Kettner, C.A. (1990). „Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids”. J. Biol. Chem. 265: 3738-3743. PMID 2105953.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.