INHBC
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| edit |
| Inhibin, beta C | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | INHBC; IHBC | ||||||||||
| Vanjski ID | OMIM: 601233 MGI: 105932 HomoloGene: 21142 GeneCards: INHBC Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3626 | 16325 | |||||||||
| Ensembl | ENSG00000175189 | ENSMUSG00000025405 | |||||||||
| UniProt | P55103 | P55104 | |||||||||
| RefSeq (mRNA) | NM_005538.2 | NM_010565.3 | |||||||||
| RefSeq (protein) | NP_005529.1 | NP_034695.1 | |||||||||
| Lokacija (UCSC) | Chr 12: 57.83 - 57.85 Mb | Chr 10: 127.36 - 127.37 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Inhibin beta C lanac je protein koji je kod ljudi kodiran INHBC genom.[1][2]
Ovaj gen protein koji je član TGF-beta familije. Ova podjedinica formira heterodimere sa beta A i beta B podjedinicama. Inhibini i aktivini, takođe članovi TGF-beta familije, su hormoni sa suprotnim destvom koji učestvuju u hipotalamusnoj, hipofiznoj, i gonadalnoj hormonskoj sekreciji, kao i u razviću i diferencijaciji raznih ćelijskih tipova.[2]
Reference[uredi | uredi kod]
- ↑ H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). „Cloning of a new member of the TGF-beta family: a putative new activin beta C chain”. Biochem Biophys Res Commun 206 (2): 608–13. DOI:10.1006/bbrc.1995.1086. PMID 7826378.
- ↑ 2,0 2,1 „Entrez Gene: INHBC inhibin, beta C”.
Literatura[uredi | uredi kod]
- Bernard DJ, Chapman SC, Woodruff TK (2001). „Mechanisms of inhibin signal transduction.”. Recent Prog. Horm. Res. 56: 417–50. DOI:10.1210/rp.56.1.417. PMID 11237224.
- Mathews LS, Vale WW (1991). „Expression cloning of an activin receptor, a predicted transmembrane serine kinase.”. Cell 65 (6): 973–82. DOI:10.1016/0092-8674(91)90549-E. PMID 1646080.
- Schmitt J, Hötten G, Jenkins NA, et al. (1997). „Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.”. Genomics 32 (3): 358–66. DOI:10.1006/geno.1996.0130. PMID 8838799.
- Thomas TZ, Chapman SM, Hong W, et al. (1998). „Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.”. Prostate 34 (1): 34–43. DOI:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386.
- Mellor SL, Cranfield M, Ries R, et al. (2001). „Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.”. J. Clin. Endocrinol. Metab. 85 (12): 4851–8. DOI:10.1210/jc.85.12.4851. PMID 11134153.
- Casagrandi D, Bearfield C, Geary J, et al. (2003). „Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.”. Mol. Hum. Reprod. 9 (4): 199–203. DOI:10.1093/molehr/gag029. PMID 12651901.
- Mellor SL, Ball EM, O'Connor AE, et al. (2003). „Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.”. Endocrinology 144 (10): 4410–9. DOI:10.1210/en.2003-0225. PMID 12960042.
- Ushiro Y, Hashimoto O, Seki M, et al. (2007). „Analysis of the function of activin betaC subunit using recombinant protein.”. J. Reprod. Dev. 52 (4): 487–95. DOI:10.1262/jrd.17110. PMID 16627954.