INHBA

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Inhibin, beta A

PDB prikaz baziran na 1nys.
Dostupne strukture
1NYS, 1NYU, 1S4Y, 2ARP, 2ARV, 2B0U, 2P6A, 3B4V
Identifikatori
SimboliINHBA; EDF; FRP
Vanjski IDOMIM147290 MGI96570 HomoloGene1653 GeneCards: INHBA Gene
Pregled RNK izražavanja
PBB GE INHBA 210511 s at tn.png
PBB GE INHBA 204926 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez362416323
EnsemblENSG00000122641ENSMUSG00000041324
UniProtP08476Q04998
RefSeq (mRNA)NM_002192.2NM_008380.1
RefSeq (protein)NP_002183.1NP_032406.1
Lokacija (UCSC)Chr 7:
41.72 - 41.74 Mb
Chr 13:
16.01 - 16.03 Mb
PubMed pretraga[1][2]

Inhibin, beta A (INHBA) je protein koji je kod ljudi kodiran INHBA genom.[1] INHBA is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects.

Funkcija[uredi - уреди | uredi izvor]

Inhibin beta A subunit zajedno sa alfa podjedinicom formira hipofizni FSH sekretorni inhibitor. Inhibin negativno reguliše proliferaciju gonadalnih stromalnih ćelija i ima supresivno dejstvo na tumour. Serumski nivoi inhibina odražavaju veličinu granulosa-ćelija tumora i mogu se koristiti kao marker za primarnu kao i rekurentnu bolest. Kod kancera prostate, izražavanje gena inhibin alfa-podjedinice je potisnuto i ne može se detektovati kod slabo diferenciranih ćelija tumora.[2]

Interakcije[uredi - уреди | uredi izvor]

INHBA formira interakcije sa ACVR2A.[3][4]

Reference[uredi - уреди | uredi izvor]

  1. Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology 122 (4): 1701–2. PMID 3345731. doi:10.1210/endo-122-4-1701. 
  2. "Entrez Gene: INHBA inhibin, beta A (activin A, activin AB alpha polypeptide)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3624. 
  3. Lewis, K A; Gray P C, Blount A L, MacConell L A, Wiater E, Bilezikjian L M, Vale W (March 2000). "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling". Nature (ENGLAND) 404 (6776): 411–4. ISSN 0028-0836. PMID 10746731. doi:10.1038/35006129. 
  4. Martens, J W; de Winter J P, Timmerman M A, McLuskey A, van Schaik R H, Themmen A P, de Jong F H (July 1997). "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells". Endocrinology (UNITED STATES) 138 (7): 2928–36. ISSN 0013-7227. PMID 9202237. doi:10.1210/en.138.7.2928. 

Literatura[uredi - уреди | uredi izvor]

  • Munz B, Hübner G, Tretter Y et al. (1999). "A novel role of activin in inflammation and repair.". J. Endocrinol. 161 (2): 187–93. PMID 10320815. doi:10.1677/joe.0.1610187. 
  • Welt C, Sidis Y, Keutmann H, Schneyer A (2002). "Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium.". Exp. Biol. Med. (Maywood) 227 (9): 724–52. PMID 12324653. 
  • Shav-Tal Y, Zipori D (2003). "The role of activin a in regulation of hemopoiesis.". Stem Cells 20 (6): 493–500. PMID 12456957. doi:10.1634/stemcells.20-6-493. 
  • Reis FM, Luisi S, Carneiro MM et al. (2005). "Activin, inhibin and the human breast.". Mol. Cell. Endocrinol. 225 (1–2): 77–82. PMID 15451571. doi:10.1016/j.mce.2004.02.016. 
  • Shao L, Frigon NL, Young AL et al. (1992). "Effect of activin A on globin gene expression in purified human erythroid progenitors". Blood 79 (3): 773–81. PMID 1310063. 
  • Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase". Cell 65 (6): 973–82. PMID 1646080. doi:10.1016/0092-8674(91)90549-E. 
  • Tanimoto K, Handa S, Ueno N et al. (1992). "Structure and sequence analysis of the human activin beta A subunit gene". DNA Seq. 2 (2): 103–10. PMID 1777673. doi:10.3109/10425179109039678. 
  • Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). "Activin B: precursor sequences, genomic structure and in vitro activities". Mol. Endocrinol. 3 (9): 1352–8. PMID 2575216. doi:10.1210/mend-3-9-1352. 
  • Barton DE, Yang-Feng TL, Mason AJ et al. (1989). "Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice". Genomics 5 (1): 91–9. PMID 2767687. doi:10.1016/0888-7543(89)90091-8. 
  • Murata M, Eto Y, Shibai H et al. (1988). "Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain". Proc. Natl. Acad. Sci. U.S.A. 85 (8): 2434–8. PMC 280011. PMID 3267209. doi:10.1073/pnas.85.8.2434. 
  • Burger HG, Igarashi M (1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology 122 (4): 1701–2. PMID 3345731. doi:10.1210/endo-122-4-1701. 
  • Mason AJ, Niall HD, Seeburg PH (1986). "Structure of two human ovarian inhibins". Biochem. Biophys. Res. Commun. 135 (3): 957–64. PMID 3754442. doi:10.1016/0006-291X(86)91021-1. 
  • Stewart AG, Milborrow HM, Ring JM et al. (1986). "Human inhibin genes. Genomic characterisation and sequencing". FEBS Lett. 206 (2): 329–34. PMID 3758355. doi:10.1016/0014-5793(86)81006-7. 
  • Sumitomo S, Inouye S, Liu XJ et al. (1995). "The heparin binding site of follistatin is involved in its interaction with activin". Biochem. Biophys. Res. Commun. 208 (1): 1–9. PMID 7887917. doi:10.1006/bbrc.1995.1297. 
  • Xu J, McKeehan K, Matsuzaki K, McKeehan WL (1995). "Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism". J. Biol. Chem. 270 (11): 6308–13. PMID 7890768. doi:10.1074/jbc.270.11.6308. 
  • Mason AJ (1994). "Functional analysis of the cysteine residues of activin A". Mol. Endocrinol. 8 (3): 325–32. PMID 8015550. doi:10.1210/me.8.3.325. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Nishihara T, Okahashi N, Ueda N (1994). "Activin A induces apoptotic cell death". Biochem. Biophys. Res. Commun. 197 (2): 985–91. PMID 8267637. doi:10.1006/bbrc.1993.2576. 
  • ten Dijke P, Ichijo H, Franzén P et al. (1993). "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity". Oncogene 8 (10): 2879–87. PMID 8397373. 
  • Tanimoto K, Yoshida E, Mita S et al. (1997). "Human activin betaA gene. Identification of novel 5' exon, functional promoter, and enhancers". J. Biol. Chem. 271 (51): 32760–9. PMID 8955111. doi:10.1074/jbc.271.51.32760. 

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