Hromopirolatna sintaza
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Hromopirolatna sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 4.3.1.26 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hromopirolatna sintaza (EC 4.3.1.26, RebD, hromopirolinsko kiselinska sintaza) je enzim sa sistematskim imenom 2-imino-3-(7-hloroindol-3-il)propanoat amonijak-lijaza (formira dihlorohromopirolat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 2-imino-3-(7-hloroindol-3-il)propanoat dihlorohromopirolat + NH3
Ovaj enzim učestvuje u biosintezi rebekamicina.
Reference[uredi | uredi kod]
- ↑ Nishizawa, T., Gruschow, S., Jayamaha, D.H., Nishizawa-Harada, C. and Sherman, D.H. (2006). „Enzymatic assembly of the bis-indole core of rebeccamycin”. J. Am. Chem. Soc. 128: 724-725. PMID 16417354.
- ↑ Howard-Jones, A.R. and Walsh, C.T. (2005). „Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD”. Biochemistry 44: 15652-15663. PMID 16313168.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.