Hromodomen

Hromodomen
	Struktura polikomb hromodomena.
Identifikatori
Simbol	Chromodomain
Pfam	PF00385
InterPro	IPR000953
SMART	SM00298
PROSITE	PS50013
SCOP	1pfb
Superfamilija	1pfb
CDD	cd00024
Dostupne PDB strukture:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	strukturni pregled

Hromodomen (hromatin organizacioni modifikar^[2]) je proteinski strukturni domen od oko 40-50 aminokiselinskih ostataka koji se često sreće kod proteina koji učestvuju u remodelovanju i manipulaciji hromatina. Domen je visoko konzerviran kod biljki i životinja, i zastupljen je u velikom broju različitih proteina mnogih genoma. Neki geni koji sadrže hromodomen imaju višestruke alternativno splajsne izoforme, neke od kojih potpuno izostavljaju hromodomen.^[3] Kod sisara, proteini koji sadrže hromodomen su odgovorni za aspekte regulacije gena vezane za hromatin remodelovanje i formiranje heterohromatinskih regiona.^[4] Proteini koji sadrže hromodomen takođe vezuju metilisane histone^[5]^[6] i javljaju se u kompleksu RNK-indukovanog transkripcionog ućutkivanja.^[7]

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Bromodomen

Literatura[uredi | uredi kod]

↑ Min J, Zhang Y, Xu RM (August 2003). „Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27”. Genes Dev. 17 (15): 1823–8. DOI:10.1101/gad.269603. PMC 196225. PMID 12897052.
↑ S Messmer, A Franke, R Paro (July 1992). „Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster.”. Genes Dev. 6 (7): 1241-1254. DOI:10.1101/gad.6.7.1241. PMID 1628830.
↑ Tajul-Arifin K, Teasdale R, Ravasi T, Humel DA, Group RIKEN GER, Members GSL, Mattick JS. (2003). „Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome”. Genome Res 13 (6B): 1416–1429. DOI:10.1101/gr.1015703. PMC 403676. PMID 12819141.
↑ Jones DO, Cowell IG, Singh PB. (2000). „Mammalian chromodomain proteins: their role in genome organisation and expression”. Bioessays 22 (2): 124–37. DOI:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032.
↑ Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T, Murzin AG, Murzina NV i dr.. (2002). „Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9”. Nature 416 (6876): 103–7. DOI:10.1038/nature722. PMID 11882902.
↑ Jacobs SA, Khorasanizadeh S. (2002). „Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail”. Science 295 (5562): 2080–3. DOI:10.1126/science.1069473. PMID 11859155.
↑ Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal S, Moazed D (2004). „RNAi-mediated targeting of heterochromatin by the RITS complex”. Science 303 (5658): 672–6. DOI:10.1126/science.1093686. PMID 14704433.

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Remodelovanje hromatina

[pmid12897052-1] Min J, Zhang Y, Xu RM (August 2003). „Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27”. Genes Dev. 17 (15): 1823–8. DOI:10.1101/gad.269603. PMC 196225. PMID 12897052.

[pmid1628830-2] S Messmer, A Franke, R Paro (July 1992). „Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster.”. Genes Dev. 6 (7): 1241-1254. DOI:10.1101/gad.6.7.1241. PMID 1628830.

[Tajul-3] Tajul-Arifin K, Teasdale R, Ravasi T, Humel DA, Group RIKEN GER, Members GSL, Mattick JS. (2003). „Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome”. Genome Res 13 (6B): 1416–1429. DOI:10.1101/gr.1015703. PMC 403676. PMID 12819141.

[Jones-4] Jones DO, Cowell IG, Singh PB. (2000). „Mammalian chromodomain proteins: their role in genome organisation and expression”. Bioessays 22 (2): 124–37. DOI:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032.

[Nielsen-5] Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T, Murzin AG, Murzina NV i dr.. (2002). „Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9”. Nature 416 (6876): 103–7. DOI:10.1038/nature722. PMID 11882902.

[Jacobs-6] Jacobs SA, Khorasanizadeh S. (2002). „Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail”. Science 295 (5562): 2080–3. DOI:10.1126/science.1069473. PMID 11859155.

[Verdel-7] Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal S, Moazed D (2004). „RNAi-mediated targeting of heterochromatin by the RITS complex”. Science 303 (5658): 672–6. DOI:10.1126/science.1093686. PMID 14704433.

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Hromodomen

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