Hondroitinska AC lijaza
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| Hondroitinska AC lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.5 | ||||||||
| CAS broj | 9047-57-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hondroitinska AC lijaza (EC 4.2.2.5, hondroitinaza, hondroitin sulfatna lijaza, hondroitin AC eliminaza, hondroitinaza AC, ChnAC) je enzim sa sistematskim imenom hondroitin AC lijaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Eliminativna degradacija polisaharida koji sadrže 1,4-beta-D-heksozaminil i 1,3-beta-D-glukuronazil veze do disaharida koji sadrže 4-dezoksi-beta-D-gluk-4-enuronozil grupe
Ovaj enzim deluje na hondroitin 4-sulfat i hondroitin 6-sulfat.
Reference[uredi | uredi kod]
- ↑ Nakada, H.I. and Wolfe, J.B. (1961). „Studies on the enzyme chondroitinase: product structure and ion effects”. Arch. Biochem. Biophys. 94: 244-251. PMID 13727579.
- ↑ Pojasek, K., Shriver, Z., Kiley, P., Venkataraman, G. and Sasisekharan, R. (2001). „Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum”. Biochem. Biophys. Res. Commun. 286: 343-351. PMID 11500043.
- ↑ Fethiere, J., Shilton, B.H., Li, Y., Allaire, M., Laliberte, M., Eggimann, B. and Cygler, M. (1998). „Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum”. Acta Crystallogr. D Biol. Crystallogr. 54: 279-280. PMID 9761894.
- ↑ Fethiere, J., Shilton, B.H., Li, Y., Allaire, M., Laliberte, M., Eggimann, B. and Cygler, M. (1998). „Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum”. Acta Crystallogr. D Biol. Crystallogr. 54: 279-280. PMID 9761894.
- ↑ Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276-6286. PMID 16336265.
- ↑ Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276-6286. PMID 16336265.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.