Hondroitinska AC lijaza

Izvor: Wikipedia
Hondroitinska AC lijaza
Identifikatori
EC broj 4.2.2.5
CAS broj 9047-57-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Hondroitinska AC lijaza (EC 4.2.2.5, hondroitinaza, hondroitin sulfatna lijaza, hondroitin AC eliminaza, hondroitinaza AC, ChnAC) je enzim sa sistematskim imenom hondroitin AC lijaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Eliminativna degradacija polisaharida koji sadrže 1,4-beta-D-heksozaminil i 1,3-beta-D-glukuronazil veze do disaharida koji sadrže 4-dezoksi-beta-D-gluk-4-enuronozil grupe

Ovaj enzim deluje na hondroitin 4-sulfat i hondroitin 6-sulfat.

Reference[uredi - уреди]

  1. Nakada, H.I. and Wolfe, J.B. (1961). "Studies on the enzyme chondroitinase: product structure and ion effects". Arch. Biochem. Biophys. 94: 244–251. PMID 13727579. 
  2. Pojasek, K., Shriver, Z., Kiley, P., Venkataraman, G. and Sasisekharan, R. (2001). "Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum". Biochem. Biophys. Res. Commun. 286: 343–351. PMID 11500043. 
  3. Fethiere, J., Shilton, B.H., Li, Y., Allaire, M., Laliberte, M., Eggimann, B. and Cygler, M. (1998). "Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum". Acta Crystallogr. D Biol. Crystallogr. 54: 279–280. PMID 9761894. 
  4. Fethiere, J., Shilton, B.H., Li, Y., Allaire, M., Laliberte, M., Eggimann, B. and Cygler, M. (1998). "Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum". Acta Crystallogr. D Biol. Crystallogr. 54: 279–280. PMID 9761894. 
  5. Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). "Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides". FEBS J. 272: 6276–6286. PMID 16336265. 
  6. Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). "Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides". FEBS J. 272: 6276–6286. PMID 16336265. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]