Holin oksidaza

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Holin oksidaza
Holin oksidaza dimer, Arthrobacter globiformis
Identifikatori
EC broj 1.1.3.17
CAS broj 9028-67-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Holin oksidaza (EC 1.1.3.17, holinska oksidaza) je enzim sa sistematskim imenom holin:kiseonik 1-oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

holin + 2 O2 +H2O betain + 2H2O2 (sveukupna reakcija)
(1a) holin + O2 betain aldehid +H2O2
(1b) betain aldehid + O2 +H2O betain +H2O2

Ovaj enzim je flavoprotein (FAD). Kod mnogih bakterija, biljki i životinja, osmoprotektant betain se sintetiše koristeći različite enzime koji katalizuju konverziju: (1) holina u betainski aldehid i (2) betain aldehida u betain.

Reference[uredi | uredi kod]

  1. Ikuta, S., Imamura, S., Misaki, H. and Horiuti, Y. (1977). „Purification and characterization of choline oxidase from Arthrobacter globiformis”. J. Biochem. (Tokyo) 82: 1741-1749. PMID 599154. 
  2. Rozwadowski, K.L., Khachatourians, G.G. and Selvaraj, G. (1991). „Choline oxidase, a catabolic enzyme in Arthrobacter pascens, facilitates adaptation to osmotic stress in Escherichia coli. J. Bacteriol. 173: 472-478. PMID 1987142. 
  3. Rand, T., Halkier, T. and Hansen, O.C. (2003). „Structural characterization and mapping of the covalently linked FAD cofactor in choline oxidase from Arthrobacter globiformis”. Biochemistry 42: 7188-7194. PMID 12795615. 
  4. Gadda, G., Powell, N.L. and Menon, P. (2004). „The trimethylammonium headgroup of choline is a major determinant for substrate binding and specificity in choline oxidase”. Arch. Biochem. Biophys. 430: 264-273. PMID 15369826. 
  5. Fan, F. and Gadda, G. (2005). „On the catalytic mechanism of choline oxidase”. J. Am. Chem. Soc. 127: 2067-2074. PMID 15713082. 
  6. Waditee, R., Tanaka, Y., Aoki, K., Hibino, T., Jikuya, H., Takano, J., Takabe, T. and Takabe, T. (2003). „Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica”. J. Biol. Chem. 278: 4932-4942. PMID 12466265. 
  7. Fan, F., Ghanem, M. and Gadda, G. (2004). „Cloning, sequence analysis, and purification of choline oxidase from Arthrobacter globiformis: a bacterial enzyme involved in osmotic stress tolerance”. Arch. Biochem. Biophys. 421: 149-158. PMID 14678796. 
  8. Gadda, G. (2003). „Kinetic mechanism of choline oxidase from Arthrobacter globiformis”. Biochim. Biophys. Acta 1646: 112-118. PMID 12637017. 

Literatura[uredi | uredi kod]

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