Holesterol 7a-monooksigenaza
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| Holesterol 7a-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.17 | ||||||||
| CAS broj | 9037-53-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Holesterol 7a-monooksigenaza (EC 1.14.13.17, holesterolna 7alfa-hidroksilaza, CYP7A1) je enzim sa sistematskim imenom holesterol,NADPH:kiseonik oksidoreduktaza (7alfa-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- holesterol + NADPH + H+ + O2 7alfa-hidroksiholesterol + NADP+ + H2O
Reference[uredi | uredi kod]
- ↑ Boyd, G.S., Grimwade, A.M. and Lawson, M.E. (1973). „Studies on rat-liver microsomal cholesterol 7α-hydroxylase”. Eur. J. Biochem. 37: 334-340. PMID 4147676.
- ↑ Mitton, J.R., Scholan, N.A. and Boyd, G.S. (1971). „The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7α-hydroxylase enzyme system”. Eur. J. Biochem. 20: 569-579. PMID 4397276.
- ↑ Ogishima, T., Deguchi, S. and Okuda, K. (1987). „Purification and characterization of cholesterol 7α-hydroxylase from rat liver microsomes”. J. Biol. Chem. 262: 7646-7650. PMID 3584134.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.