Hidroksiizouratna hidrolaza
(Preusmjereno sa stranice Hidroksiizourat hidrolaza)
| Hidroksiizouratna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.2.17 | ||||||||
| CAS broj | 255885-20-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hidroksiizouratna hidrolaza (EC 3.5.2.17, HIUHaza, 5-hidroksiizouratna hidrolaza) je enzim sa sistematskim imenom 5-hidroksiizourat amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-hidroksiizourat + H2O 5-hidroksi-2-okso-4-ureido-2,5-dihidro-1H-imidazol-5-karboksilat
Ova reakcija je prvi stupan konverzije 5-hidroksiizourata u S-alantoin.
Reference[uredi | uredi kod]
- ↑ Raychaudhuri, A. and Tipton, P.A. (2003). „A familiar motif in a new context: the catalytic mechanism of hydroxyisourate hydrolase”. Biochemistry 42: 6848-6852. PMID 12779339.
- ↑ Raychaudhuri, A. and Tipton, P.A. (2002). „Cloning and expression of the gene for soybean hydroxyisourate hydrolase. Localization and implications for function and mechanism”. Plant Physiol. 130: 2061-2068. PMID 12481089.
- ↑ Sarma, A.D., Serfozo, P., Kahn, K. and Tipton, P.A. (1999). „Identification and purification of hydroxyisourate hydrolase, a novel ureide-metabolizing enzyme”. J. Biol. Chem. 274: 33863-33865. PMID 10567345.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.