Hidroksifenilacetonitril 2-monooksigenaza
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| Hidroksifenilacetonitril 2-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.42 | ||||||||
| CAS broj | 89287-41-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hidroksifenilacetonitril 2-monooksigenaza (EC 1.14.13.42, 4-hidroksifenilacetonitrilna monooksigenaza, 4-hidroksifenilacetonitrilna hidroksilaza) je enzim sa sistematskim imenom 4-hidroksifenilacetonitril,NADPH:kiseonik oksidoreduktaza (2-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-hidroksifenilacetonitril + NADPH + H+ + O2 4-hidroksimandelonitril + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450).
Reference[uredi | uredi kod]
- ↑ Halkier, B.A. and Møller, B.L. (1990). „The biosynthesis of cyanogenic glucosides in higher plants. Identification of three hydroxylation steps in the biosynthesis of dhurrin in Sorghum bicolor (L.) Moench and the involvement of 1-ACI-nitro-2-(p-hydroxyphenyl)ethane as an intermediate”. J. Biol. Chem. 265: 21114-21121. PMID 2250015.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.