Heksaprenil-difosfat sintaza ((2E,6E)-farnezil-difosfat specifična)
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| Heksaprenil-difosfat sintaza ((2E,6E)-farnezil-difosfat specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.83 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Heksaprenil-difosfat sintaza ((2E,6E)-farnezil-difosfat specifična) (EC 2.5.1.83, HexPS, heksaprenil pirofosfatna sintetaza, heksaprenil difosfatna sintaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat:izopentenil-difosfat farneziltranstransferaza (dodaje 3 izopentenilne jedinice).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat + 3 izopentenil difosfat 3 difosfat + sve-trans-heksaprenil difosfat
Ovaj enzim preferentno deluje na geranilgeranil difosfat.
Reference[uredi | uredi kod]
- ↑ Fujii, H., Koyama, T. and Ogura, K. (1982). „Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components”. J. Biol. Chem. 257: 14610-14612. PMID 7174655.
- ↑ Shimizu, N., Koyama, T. and Ogura, K. (1998). „Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase”. J. Bacteriol. 180: 1578-1581. PMID 9515931.
- ↑ Nagaki, M., Kimura, K., Kimura, H., Maki, Y., Goto, E., Nishino, T. and Koyama, T. (2001). „Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases”. Bioorg. Med. Chem. Lett. 11: 2157-2159. PMID 11514159.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.