HTR3A

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5-hidroksitriptaminski (serotoninski) receptor 3A, jonotropni
Identifikatori
SimboliHTR3A; 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3
Vanjski IDOMIM182139 MGI96282 HomoloGene671 IUPHAR: 5-HT3A GeneCards: HTR3A Gene
Pregled RNK izražavanja
PBB GE HTR3A 216615 s at tn.png
PBB GE HTR3A 217002 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez335915561
EnsemblENSG00000166736ENSMUSG00000032269
UniProtP46098P23979
RefSeq (mRNA)NM_000869NM_001099644
RefSeq (protein)NP_000860NP_001093114
Lokacija (UCSC)Chr 11:
113.85 - 113.86 Mb
Chr 9:
48.9 - 48.91 Mb
PubMed pretraga[1][2]

5-hidroksitriptaminski receptor 3A je protein koji je kod čoveka kodiran HTR3A genom.[1][2]

Produkt ovog gena pripada receptorskoj familiji ligandom konstrolisanih jonskih kanala. Ovaj gen kodira podjedinicu A tipa 3 receptora za 5-hidroksitriptamin (serotonin), biogeni hormon koji deluje kao neurotransmiter, hormon, i mitogen. Ovaj receptor uzrokujue brze, depolaricione response u neuronima nakon aktivacije. Heteromerna kombinacija A i B podjedinica je neophodna da bi se formirao potpuno funkcionalni receptor. Homomerni receptor bilo koja podjednice imaju veoma nisku provodnost i malu amplitudu responsa. Alternativno splajsovane transkriptne varijante koje kodiraju različite izoforme su poznate.[3]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (Feb 1996). "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics 29 (1): 304–5. PMID 8530095. doi:10.1006/geno.1995.1254.  Check date values in: |date= (help)
  2. Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (Jul 2003). "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature 424 (6946): 321–4. PMID 12867984. doi:10.1038/nature01788.  Check date values in: |date= (help)
  3. "Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3359. 

Literatura[uredi - уреди | uredi izvor]

  • Miyake A, Mochizuki S, Takemoto Y, Akuzawa S (1995). "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.". Mol. Pharmacol. 48 (3): 407–16. PMID 7565620. 
  • Uetz P, Abdelatty F, Villarroel A et al. (1994). "Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11.". FEBS Lett. 339 (3): 302–6. PMID 8112471. doi:10.1016/0014-5793(94)80435-4. 
  • Belelli D, Balcarek JM, Hope AG et al. (1996). "Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.". Mol. Pharmacol. 48 (6): 1054–62. PMID 8848005. 
  • Brüss M, Göthert M, Hayer M, Bönisch H (1999). "Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs.". Ann. N. Y. Acad. Sci. 861: 234–5. PMID 9928262. doi:10.1111/j.1749-6632.1998.tb10196.x. 
  • Davies PA, Pistis M, Hanna MC et al. (1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function.". Nature 397 (6717): 359–63. PMID 9950429. doi:10.1038/16941. 
  • Brüss M, Eucker T, Göthert M, Bönisch H (2000). "Exon-intron organization of the human 5-HT3A receptor gene.". Neuropharmacology 39 (2): 308–15. PMID 10670426. doi:10.1016/S0028-3908(99)00116-1. 
  • Marazziti D, Betti L, Giannaccini G et al. (2002). "Distribution of [3H]GR65630 binding in human brain postmortem.". Neurochem. Res. 26 (3): 187–90. PMID 11495540. doi:10.1023/A:1010939530412. 
  • Spier AD, Lummis SC (2003). "Immunological characterization of 5-HT3 receptor transmembrane topology.". J. Mol. Neurosci. 18 (3): 169–78. PMID 12059035. doi:10.1385/JMN:18:3:169. 
  • Boyd GW, Low P, Dunlop JI et al. (2002). "Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins.". Mol. Cell. Neurosci. 21 (1): 38–50. PMID 12359150. doi:10.1006/mcne.2002.1160. 
  • Hapfelmeier G, Haseneder R, Lampadius K et al. (2003). "Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics.". Neurosci. Lett. 335 (1): 44–8. PMID 12457738. doi:10.1016/S0304-3940(02)01156-4. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Pick H, Preuss AK, Mayer M et al. (2003). "Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells". Biochemistry 42 (4): 877–84. PMID 12549905. doi:10.1021/bi026576d. 
  • Choi S, Lee JH, Oh S et al. (2003). "Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes". Mol. Cells 15 (1): 108–13. PMID 12661769. 
  • Boyd GW, Doward AI, Kirkness EF et al. (2003). "Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal". J. Biol. Chem. 278 (30): 27681–7. PMID 12750374. doi:10.1074/jbc.M304938200. 
  • Sun H, Hu XQ, Moradel EM et al. (2003). "Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C". J. Biol. Chem. 278 (36): 34150–7. PMID 12791692. doi:10.1074/jbc.M303584200. 
  • Maksay G, Bikádi Z, Simonyi M (2004). "Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models". J. Recept. Signal Transduct. Res. 23 (2–3): 255–70. PMID 14626451. doi:10.1081/RRS-120025568. 
  • Kaiser R, Tremblay PB, Sezer O et al. (2004). "Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists". Pharmacogenetics 14 (5): 271–8. PMID 15115912. doi:10.1097/00008571-200405000-00001. 
  • Panicker S, Cruz H, Arrabit C et al. (2004). "Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor". J. Biol. Chem. 279 (27): 28149–58. PMID 15131114. doi:10.1074/jbc.M403545200. 

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