Glutationska hidrolaza

Iz Wikipedije, slobodne enciklopedije
Glutationska hidrolaza
Identifikatori
EC broj 3.4.19.13
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glutationska hidrolaza (EC 3.4.19.13, glutationaza, GGT, gama-glutamiltranspeptidaza) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

glutation + H2O L-cisteinilglicin + L-glutamat

Ovaj protein takođe deluje kao enzim EC 2.3.2.2 (gama-glutamiltransferaza).

Reference[uredi - уреди | uredi izvor]

  1. Hanigan, M.H. and Ricketts, W.A. (1993). "Extracellular glutathione is a source of cysteine for cells that express γ-glutamyl transpeptidase". Biochemistry 32: 6302–6306. PMID 8099811. 
  2. Suzuki, H. and Kumagai, H. (2002). "Autocatalytic processing of γ-glutamyltranspeptidase". J. Biol. Chem. 277: 43536–43543. PMID 12207027. 
  3. Okada, T., Suzuki, H., Wada, K., Kumagai, H. and Fukuyama, K. (2006). "Crystal structures of γ-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate". Proc. Natl. Acad. Sci. USA 103: 6471–6476. PMID 16618936. 
  4. Boanca, G., Sand, A., Okada, T., Suzuki, H., Kumagai, H., Fukuyama, K. and Barycki, J.J. (2007). "Autoprocessing of Helicobacter pylori γ-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad". J. Biol. Chem. 282: 534–541. PMID 17107958. 
  5. Okada, T., Suzuki, H., Wada, K., Kumagai, H. and Fukuyama, K. (2007). "Crystal structure of the γ-glutamyltranspeptidase precursor protein from Escherichia coli. Structural changes upon autocatalytic processing and implications for the maturation mechanism". J. Biol. Chem. 282: 2433–2439. PMID 17135273. 
  6. Wickham, S., West, M.B., Cook, P.F. and Hanigan, M.H. (2011). "Gamma-glutamyl compounds: substrate specificity of γ-glutamyl transpeptidase enzymes". Anal. Biochem. 414: 208–214. PMID 21447318. 
  7. Carter, B.Z., Wiseman, A.L., Orkiszewski, R., Ballard, K.D., Ou, C.N. and Lieberman, M.W. (1997). "Metabolism of leukotriene C4 in γ-glutamyl transpeptidase-deficient mice". J. Biol. Chem. 272: 12305–12310. PMID 9139674. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]