Glutamin-(asparagin-)aza
(Preusmjereno sa stranice Glutamin-(asparagin-)ase)
| Glutamin-(asparagin-)aza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.38 | ||||||||
| CAS broj | 39335-03-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutamin-(asparagin-)aza (EC 3.5.1.38, glutaminaza-asparaginaza, ansB (gen), L-asparagin/L-glutamin amidohidrolaza, L-ASNaza/L-GLNaza) je enzim sa sistematskim imenom L-glutamin(L-asparagin) amidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Enzim iz bakterije Achromobacter hidrolizuje L-asparagin sa 0.8 brzine hidrolize L-glutamina.
Reference[uredi | uredi kod]
- ↑ Roberts, J., Holcenberg, J.S. and Dolowy, W.C. (1972). „Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity”. J. Biol. Chem. 247: 84-90. PMID 5017769.
- ↑ Tanaka, S., Robinson, E.A., Appella, E., Miller, M., Ammon, H.L., Roberts, J., Weber, I.T. and Wlodawer, A. (1988). „Structures of amidohydrolases. Amino acid sequence of a glutaminase-asparaginase from Acinetobacter glutaminasificans and preliminary crystallographic data for an asparaginase from Erwinia chrysanthemi”. J. Biol. Chem. 263: 8583-8591. PMID 3379033.
- ↑ Lubkowski, J., Wlodawer, A., Ammon, H.L., Copeland, T.D. and Swain, A.L. (1994). „Structural characterization of Pseudomonas 7A glutaminase-asparaginase”. Biochemistry 33: 10257-10265. PMID 8068664.
- ↑ Ortlund, E., Lacount, M.W., Lewinski, K. and Lebioda, L. (2000). „Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu”. Biochemistry 39: 1199-1204. PMID 10684596.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.