Glukuronil-galaktozil-proteoglikan 4-a-N-acetilglukozaminiltransferaza
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| Glukuronil-galaktozil-proteoglikan 4-a-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.223 | ||||||||
| CAS broj | 179241-74-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glukuronil-galaktozil-proteoglikan 4-a-N-acetilglukozaminiltransferaza (EC 2.4.1.223, alfa-N-acetilglukozaminiltransferaza I, alfa1,4-N-acetilglukozaminiltransferaza, glukuronazilgalaktozil-proteoglikan 4-alfa-N-acetilglukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-glukuronasil-(1->3)-beta-D-galaktozil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-ksilosil-proteoglikan 4IV-alfa-N-acetil-D-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-glukozamin + beta-D-glukuronazil-(1->3)-beta-D-galaktozil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-ksilozil-proteoglikan UDP + alfa-N-acetil-D-glukozaminil-(1->4)-beta-D-glukuronazil-(1->3)-beta-D-galaktozil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-ksilozil-proteoglikan
Ovaj enzim učestvuje u inicijaciji sinteze heparina i heparan sulfata.
Reference[uredi | uredi kod]
- ↑ Kitagawa, H., Shimakawa, H. and Sugahara, K. (1999). „The tumor suppressor EXT-like gene EXTL2 encodes an α1,4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate”. J. Biol. Chem. 274: 13933-13937. PMID 10318803.
- ↑ Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate”. J. Biol. Chem. 276: 4834-4838. PMID 11121397.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.