Glikoprotein 6-a-L-fukoziltransferaza
| Glikoprotein 6-a-L-fukoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.68 | ||||||||
| CAS broj | 2605491 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glikoprotein 6-a-L-fukoziltransferaza (EC 2.4.1.68, GDP-fukoza-glikoproteinska fukoziltransferaza, GDP-L-Fuc:N-acetil-beta-D-glukozaminidna alfa1->6 fukoziltransferaza, GDP-L-fukoza-glikoproteinska fukoziltransferaza, glikoproteinska fukoziltransferaza, guanozin difosfofukoza-glikoproteinska fukoziltransferaza, GDP-L-fukoza:glikoprotein (L-fukoza to asparagin-vezani N-acetilglukozamin of 4-NN-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-(N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6))-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-N-acetil-beta-D-glukozaminil}asparagin) 6-alfa-L-fukoziltransferaza, FucT) je enzim sa sistematskim imenom GDP-beta-L-fukoza:glikoprotein (L-fukoza za asparagin-vezani N-acetilglukozamin N4- {N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-(N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6))-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-N-acetil-beta-D-glukozaminil}asparagin) 6-alfa-L-fukoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-beta-L-fukoza + N4-{N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-[N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6)]-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-N-acetil-beta-D-glukozaminil}asparagin GDP + N4-{N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-[N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6)]-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-[alfa-L-fukozil-(1->6)]-N-acetil-beta-D-glukozaminil}asparagin
Ovaj enzim katalizuje reakciju sličnu reakciji koju posreduje enzim EC 2.4.1.214, glikoprotein 3-alfa-L-fukoziltransferaza.
Reference[uredi | uredi kod]
- ↑ Longmore, G.D. and Schachter, H. (1982). „Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-β-D-glucoside (Fuc → Asn-linked GlcNAc) 6-α-L-fucosyltransferase in a Golgi-rich fraction from porcine liver”. Carbohydr. Res. 100: 365-392. PMID 7083256.
- ↑ Voynow, J.A., Scanlin, T.F. and Glick, M.C. (1988). „A quantitative method for GDP-L-Fuc:N-acetyl-β-D-glucosaminide α1→6fucosyltransferase activity with lectin affinity chromatography”. Anal. Biochem. 168: 367-373. PMID 3364733.
- ↑ Uozumi, N., Yanagidani, S., Miyoshi, E., Ihara, Y., Sakuma, T., Gao, C.-X., Teshima, T., Fujii, S., Shiba, T. and Taniguchi, N. (1996). „Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-β-D-glucosaminide α1→6fucosyltransferase”. J. Biol. Chem. 271: 27810-27817. PMID 8910378.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.