Glikohenodezoksiholat sulfotransferaza
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| Glikohenodezoksiholat sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.34 | ||||||||
| CAS broj | 72668-90-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glikohenodezoksiholat sulfotransferaza (EC 2.8.2.34, žučna kiselina:3'-fosfoadenozin-5'-fosfosulfat sulfotransferaza, žučna kiselina:PAPS:sulfotransferaza, BAST) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:glikohenodezoksiholat 7-sulfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfoadenilil sulfat + glikohenodezoksiholat adenozin 3',5'-bisfosfat + glikohenodezoksiholat 7-sulfat
Ovaj enzim specifično sulfatiše glikohenodezoksiholat u 7alfa-poziciji.
Reference[uredi | uredi kod]
- ↑ Barnes, S., Burhol, P.G., Zander, R., Haggstrom, G., Settine, R.L. and Hirschowitz, B.I. (1979). „Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters”. J. Lipid Res. 20: 952-959. PMID 533830.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.