Glicerofosfolipid aciltransferaza (KoA-zavisna)
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| Glicerofosfolipid aciltransferaza (KoA-zavisna) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.148 | ||||||||
| CAS broj | 9054-54-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glicerofosfolipid aciltransferaza (KoA-zavisna) (EC 2.3.1.148) je enzim sa sistematskim imenom 1-organil-2-acil-sn-glicero-3-fosfoholin:1-organil-2-lizo-sn-glicero-3-fosfoetanolamin aciltransferaza (KoA-zavisna).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-organil-2-acil-sn-glicero-3-fosfoholin + 1-organil-2-lizo-sn-glicero-3-fosfoeetanolamin 1-organil-2-acil-sn-glicero-3-fosfoeetanolamin + 1-organil-2-lizo-sn-glicero-3-fosfoholin
Ovaj enzim katalizuje transfer arahidonata i drugih polienoinskih masnih kiselina sa glicerofosfolipida koji sadrže holin ili etanolamin na sn-2 poziciju lizo-glicerofosfolipida.
Reference[uredi | uredi kod]
- ↑ Irvine, R.F., Dawson, R.M.C. (1979). „Transfer of arachidonic acid between phospholipids in rat liver microsomes”. Biochem. Biophys. Res. Commun. 91: 1399-1405. PMID 526311.
- ↑ Robinson, M., Blank, M.L., Snyder, F. (1985). „Acylation of lysophospholipids by rabbit alveolar macrophages. Specific CoA-dependent and CoA-independent reactions”. J. Biol. Chem. 260: 7889-7895. PMID 4008481.
- ↑ Snyder, F., Lee, T.C., Blank, M.L. (1992). „The role of transacylases in the metabolism of arachidonate and platelet-activating factor”. Prog. Lipid Res. 31: 65-86. PMID 1641397.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.