Geranilgeranilglicerol-fosfat geranilgeraniltransferaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Geranilgeranilglicerol-fosfat geranilgeraniltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.42 | ||||||||
| CAS broj | 124650-68-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Geranilgeranilglicerol-fosfat geranilgeraniltransferaza (EC 2.5.1.42, geranilgeraniloksiglicerol fosfat geranilgeraniltransferaza, geranilgeraniltransferaza II, (S)-2,3-di-O-geranilgeranilgliceril fosfat sintaza, DGGGP sintaza, DGGGPS) je enzim sa sistematskim imenom geranilgeranil difosfat:sn-3-O-(geranilgeranil)glicerol 1-fosfat geranilgeraniltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranilgeranil difosfat + sn-3-O-(geranilgeranil)glicerol 1-fosfat difosfat + 2,3-bis-O-(geranilgeranil)glicerol 1-fosfat
Ovaj enzim je integralni membranski protein koji posreduje drugu reakciju prenil transfera pri formiranju polarnih membranskih lipida kod arheja. Za njegovo dejstvo su neophodni divalentni metalni katjoni, kao što su Mg2+ ili Mn2+.
Reference[uredi | uredi kod]
- ↑ Zhang, D.-L., Daniels, L. and Poulter, C.D. (1990). „Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction”. J. Am. Chem. Soc. 112: 1264-1265.
- ↑ Hemmi, H., Shibuya, K., Takahashi, Y., Nakayama, T. and Nishino, T. (2004). „(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids”. J. Biol. Chem. 279: 50197-50203. PMID 15356000.
- ↑ Morii, H., Nishihara, M. and Koga, Y. (2000). „CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus”. J. Biol. Chem. 275: 36568-36574. PMID 10960477.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.