Gastriksin
| Gastriksin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Heterotetramer (pro)gastriksina (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.23.3 | ||||||||
| CAS broj | 9012-71-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Gastriksin (EC 3.4.23.3, pepsin C, pig parapepsin II, parapepsin II) je enzim.[1][2][3][4][5][6][7]
Gastriksin je asparaginska proteinaza koja pripada A1 skupini peptidaza. Kodirani protein je probavni enzim koji se proizvodi u želucu i predstavlja važnu komponentu sluznice želuca. Ovaj protein se također luči u serum.
Sintetizira se kao inaktivni zimogen u kojem je uključen visoko osnovni prosegment. Ovaj enzim se pri niskom pH pretvara u svoj aktivni zreli oblik, i to uzastopnim cijepanjem prosegmenta koje izvodi enzim sam.
- ↑ Ryle, A.P. (1970). „The porcine pepsins and pepsinogens”. Methods Enzymol. 19: 316-336.
- ↑ Tang, J. (1970). „Gastricsin and pepsin”. Methods Enzymol. 19: 406-421.
- ↑ Foltmann, B. (1981). „Gastric proteinases - structure, function, evolution and mechanism of action”. Essays Biochem. 17: 52-84. PMID 6795036.
- ↑ Foltmann, B. and Jensen, A.L. (1982). „Human progastricsin - analysis of intermediates during activation into gastricsin and determination of the amino-acid sequence of the propart”. Eur. J. Biochem. 128: 63-70. PMID 6816595.
- ↑ Martin, P., Trieu-Cuot, P., Collin, J.-C. and Ribadeau Dumas, B. (1982). „Purification and characterization of bovine gastricsin”. Eur. J. Biochem. 122: 31-39. PMID 6800788.
- ↑ Reid, W.A., Vongsorasak, L., Svasti, J., Valler, M.J. and Kay, J. (1984). „Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate”. Cell Tissue Res. 236: 597-600. PMID 6432332.
- ↑ Hayano, T., Sogawa, K., Ichihara, Y., Fujii-Kuriyama, Y. and Takahasi, K. (1988). „Primary structure of human pepsinogen C gene”. J. Biol. Chem. 263: 1382-1385. PMID 3335549.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.