Galmik

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Galmik
Klinički podaci
Identifikatori
ATC kod ?
PubChem[1][2] 11636593
ChEMBL[3] CHEMBL578918 YesY
Hemijski podaci
Formula C51H60N10O11 
Mol. masa 989,080
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Galmik je lek koji deluje kao selektivni, ne-peptidni agonist galaninskih receptora.[4] On je pokazao antiepileptičke, antidepresivne i analgetske efekte u životinjskim studijama,[5] ali isto tako inhibira memorijske funkcije.[6]

Literatura[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (November 2004). "Synthesis of galmic: a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America 101 (48): 16727–32. PMC 534730. PMID 15557002. doi:10.1073/pnas.0407543101. 
  5. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). "Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests". Proceedings of the National Academy of Sciences of the United States of America 101 (28): 10470–5. PMC 478593. PMID 15240875. doi:10.1073/pnas.0403802101. 
  6. Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides 39 (3): 249–51. PMID 15944018. doi:10.1016/j.npep.2004.12.010. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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