GalNAc5-diNAcBac-PP-undekaprenol beta-1,3-glukoziltransferaza
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| GalNAc5-diNAcBac-PP-undekaprenol beta-1,3-glukoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.293 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
GalNAc5-diNAcBac-PP-undekaprenol beta-1,3-glukoziltransferaza (EC 2.4.1.293, PglI) je enzim sa sistematskim imenom UDP-alfa-D-glukoza:(GalNAc-alfa-(1->4))4-GalNAc-alfa-(1->3)-diNAcBac-difosfo-tritrans,heptacis-undekaprenol 3-beta-D-glukoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-glukoza + [GalNAc-alfa-(1->4)]4-GalNAc-alfa-(1->3)-diNAcBac-difosfo-tritrans,heptacis-undekaprenol UDP +
[GalNAc-alfa-(1->4)]2-[Glc-beta-(1->3)]-[GalNAc-alfa-(1->4)]2-GalNAc-alfa-(1->3)-diNAcBac-difosfo-tritrans,heptacis-undekaprenol
Ovaj enzim je izolovan iz Campylobacter jejuni.
Reference[uredi | uredi kod]
- ↑ Glover, K.J., Weerapana, E. and Imperiali, B. (2005). „In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation”. Proc. Natl. Acad. Sci. USA 102: 14255-14259. PMID 16186480.
- ↑ Kelly, J., Jarrell, H., Millar, L., Tessier, L., Fiori, L.M., Lau, P.C., Allan, B. and Szymanski, C.M. (2006). „Biosynthesis of the N-linked glycan in Campylobacter jejuni and addition onto protein through block transfer”. J. Bacteriol. 188: 2427-2434. PMID 16547029.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.