GalNAc-alfa-(1-4)-GalNAc-alfa-(1-3)-diNAcBac-PP-undekaprenol alfa-1,4-N-acetil-D-galaktozaminiltransferaza
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| GalNAc-alfa-(1->4)-GalNAc-alfa-(1->3)-diNAcBac-PP-undekaprenol alfa-1,4-N-acetil-D-galaktozaminiltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.1.292 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GalNAc-alfa-(1->4)-GalNAc-alfa-(1->3)-diNAcBac-PP-undekaprenol alfa-1,4-N-acetil-D-galaktozaminiltransferaza (EC 2.4.1.292, PglH) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-galaktozamin:GalNAc-alfa-(1->4)-GalNAc-alfa-(1->3)-diNAcBac-PP-tritrans,heptacis-undekaprenol 4-alfa-N-acetil-D-galaktozaminiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3 UDP-N-acetil-alfa-D-galaktozamin + GalNAc-alfa-(1->4)-GalNAc-alfa-(1->3)-diNAcBac-PP-tritrans,heptacis-undekaprenol 3 UDP + [GalNAc-alfa-(1->4)]4-GalNAc-alfa-(1->3)-diNAcBac-PP-tritrans,heptacis-undekaprenol
Ovaj enzim je izolovan iz Campylobacter jejuni.
Reference[uredi | uredi kod]
- ↑ Glover, K.J., Weerapana, E. and Imperiali, B. (2005). „In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation”. Proc. Natl. Acad. Sci. USA 102: 14255-14259. PMID 16186480.
- ↑ Troutman, J.M. and Imperiali, B. (2009). „Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions”. Biochemistry 48: 2807-2816. PMID 19159314.
- ↑ Borud, B., Viburiene, R., Hartley, M.D., Paulsen, B.S., Egge-Jacobsen, W., Imperiali, B. and Koomey, M. (2011). „Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system”. Proc. Natl. Acad. Sci. USA 108: 9643-9648. PMID 21606362.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
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