GDP-manozna 4,6-dehidrataza
(Preusmjereno sa stranice GDP-manoza 4,6-dehidrataza)
| GDP-manozna 4,6-dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.47 | ||||||||
| CAS broj | 37211-59-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
GDP-manozna 4,6-dehidrataza (EC 4.2.1.47, guanozin 5'-difosfat-D-manoza oksidoreduktaza, guanozin difosfomanoza oksidoreduktaza, guanozin difosfomanoza 4,6-dehidrataza, GDP-D-manoza dehidrataza, GDP-D-manoza 4,6-dehidrataza, Gmd, GDP-manoza 4,6-hidrolijaza) je enzim sa sistematskim imenom GDP-manoza 4,6-hidrolijaza (formira GDP-4-dehidro-6-dezoksi-D-manoza).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-manoza GDP-4-dehidro-6-dezoksi-D-manoza + H2O
Bakterijski enzim funkcioniše u prisustvu NAD+.
Reference[uredi | uredi kod]
- ↑ Elbein, A.D. and Heath, E.C. (1965). „The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. II. Guanosine diphosphate 4-keto-6-deoxy-D-mannose, an intermediate in the biosynthesis of guanosine diphosphate colitose”. J. Biol. Chem. 240: 1926-1931. PMID 14299611.
- ↑ Liao, T.-H. and Barber, G.A. (1972). „Purification of guanosine 5′-diphosphate D-mannose oxidoreductase from Phaseolus vulgaris”. Biochim. Biophys. Acta 276: 85-93. PMID 5047712.
- ↑ Melo, A., Elliott, H. and Glaser, L. (1968). „The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase”. J. Biol. Chem. 243: 1467-1474. PMID 4869560.
- ↑ Sullivan, F.X., Kumar, R., Kriz, R., Stahl, M., Xu, G.Y., Rouse, J., Chang, X.J., Boodhoo, A., Potvin, B. and Cumming, D.A. (1988). „Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro”. J. Biol. Chem. 273: 8193-8202. PMID 9525924.
- ↑ Kneidinger, B., Graninger, M., Adam, G., Puchberger, M., Kosma, P., Zayni, S. and Messner, P. (2001). „Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T”. J. Biol. Chem. 276: 5577-5583. PMID 11096116.
- ↑ Mulichak, A.M., Bonin, C.P., Reiter, W.D. and Garavito, R.M. (2000). „Structure of the MUR1 GDP-mannose 4,6-dehydratase from Arabidopsis thaliana: implications for ligand binding and specificity”. Biochemistry 41: 15578-15589. PMID 12501186.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.