GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza
Prijeđi na navigaciju
Prijeđi na pretragu
| GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.257 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza (EC 2.4.1.257, GDP-Man:Man2GlcNAc2-PP-Dol alfa-1,6-manoziltransferaza, Alg2 manoziltransferaza, ALG2 (gen), GDP-Man:Man1GlcNAc2-PP-dolihol manoziltransferaza) je enzim sa sistematskim imenom GDP-D-manoza:D-Man-alfa-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-6-manoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-D-manoza + D-Man-alfa-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol GDP + D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol
Biosinteza of asparaginom vezanih glikoproteina koristi dolihil difosfat-vezani glikozilni donor.
Reference[uredi | uredi kod]
- ↑ Kampf, M., Absmanner, B., Schwarz, M. and Lehle, L. (2009). „Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional α1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis”. J. Biol. Chem. 284: 11900-11912. PMID 19282279.
- ↑ O'Reilly, M.K., Zhang, G. and Imperiali, B. (2006). „In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis”. Biochemistry 45: 9593-9603. PMID 16878994.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.