GDP-L-fukoza sintaza
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| GDP-L-fukoza sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.271 | ||||||||
| CAS broj | 113756-18-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GDP-L-fukoza sintaza (EC 1.1.1.271, GDP-4-keto-6-dezoksi-D-manoza-3,5-epimerase-4-reduktaza, GDP-L-fukoza:NADP+ 4-oksidoreduktaza (3,5-epimerizacija)) je enzim sa sistematskim imenom GDP-beta-L-fukoza:NADP+ 4-oksidoreduktaza (3,5-epimerizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-beta-L-fukoza + NADP+ GDP-4-dehidro-6-dezoksi-alfa-D-manoza + NADPH + H+
Enzimi čoveka i Escherichia coli koriste NADH umesto NADPH u izvesnoj meri.
Reference[uredi | uredi kod]
- ↑ Chang, S., Duerr, B. and Serif, G. (1988). „An epimerase-reductase in L-fucose synthesis”. J. Biol. Chem. 263: 1693-1697. PMID 3338988.
- ↑ Mattila, P., Räbinä, J, Hortling, S., Jelin, J. and Renkonen, R. (2000). „Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae”. Glycobiology 10: 1041-1047. PMID 11030750.
- ↑ Menon, S., Stahl, M., Kumar, R., Xu, G.-Y. and Sullivan, F. (1999). „Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli”. J. Biol. Chem. 274: 26743-26750. PMID 10480878.
- ↑ Somers, W.S., Stahl, M.L. and Sullivan, F.X. (1998). „GDP-fucose synthetase from Escherichia coli: Structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site”. Structure 6: 1601-1612. PMID 9862812.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.