GDP-4-dehidro-D-ramnoza reduktaza
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| GDP-4-dehidro-D-ramnoza reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.187 | ||||||||
| CAS broj | 9075-56-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GDP-4-dehidro-D-ramnoza reduktaza (EC 1.1.1.187, GDP-4-keto-6-dezoksi-D-manoza reduktaza, GDP-4-keto-D-ramnoza reduktaza, guanozin difosfat-4-keto-D-ramnoza reduktaza, GDP-6-dezoksi-D-manoza:NAD(P)+ 4-oksidoreduktaza) je enzim sa sistematskim imenom GDP-6-dezoksi-alfa-D-manoza:NAD(P)+ 4-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- # GDP-6-dezoksi-alfa-D-manoza + NAD(P)+ GDP-4-dehidro-6-dezoksi-alfa-D-manoza + NAD(P)H + H+
- GDP-6-dezoksi-alfa-D-taloza + NAD(P)+ GDP-4-dehidro-6-dezoksi-alfa-D-manoza + NAD(P)H + H+
Enzim, koji deluje u suprotnom smeru od prikazanog, formira smešu GDP-alfa-D-ramnoze i njenog C-4 epimera, GDP-6-dezoksi-alfa-D-taloze, cf. EC 1.1.1.281, GDP-4-dehidro-6-dezoksi-D-manoza reduktaza i EC 1.1.1.135, GDP-6-dezoksi-D-taloza 4-dehidrogenaza.
Reference[uredi | uredi kod]
- ↑ Barber, G.A. (1968). „The synthesis of guanosine 5′-diphosphate D-rhamnose by enzymes of a higher plant”. Biochim. Biophys. Acta 165: 68-75. PMID 4386238.
- ↑ Winkler, N.W. and Markovitz, A. (1971). „Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme”. J. Biol. Chem. 246: 5868-5876. PMID 4398966.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.