Fosfonoacetaldehidna hidrolaza
(Preusmjereno sa stranice Fosfonoacetaldehid hidrolaza)
| Fosfonoacetaldehidna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.11.1.1 | ||||||||
| CAS broj | 37289-42-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfonoacetaldehidna hidrolaza (EC 3.11.1.1, fosfonataza, 2-fosfonoacetilaldehidna fosfonohidrolaza) je enzim sa sistematskim imenom 2-oksoetilfosfonat fosfonohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fosfonoacetaldehid + H2O acetaldehid + fosfat
Ovaj enzim destabilizuje C-P vezu, putem formiranja imina između lizinskih ostataka i karbonilnih grupa supstrata.
Reference[uredi | uredi kod]
- ↑ La Nauze, J.M. and Rosenberg, H. (1968). „The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus”. Biochim. Biophys. Acta 165: 438-447. PMID 4982500.
- ↑ La Nauze, J.M., Rosenberg, H. and Shaw, D.C. (1970). „The enzymic cleavage of the carbon-phosphorus bond: purification and properties of phosphonatase”. Biochim. Biophys. Acta 212: 332-350. PMID 4989158.
- ↑ La Nauze, J.M., Coggins, J.R. and Dixon, H.B.F. (1977). „Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase”. Biochem. J. 165: 409-411. PMID 200222.
- ↑ Olsen, D.B., Hepburn, T.W., Moos, M., Mariano, P.S. and Dunaway-Mariano, D. (1988). „Substrate binding and catalytic groups of the P-C bond cleaving enzyme, phosphonoacetaldehyde hydrolase”. Biochemistry 27: 2229-2234. PMID 3132206.
- ↑ Baker, A.S., Ciocci, M.J., Metcalf, W.W., Kim, J., Babbitt, P.C., Wanner, B.L., Martin, B.M. and Dunaway-Mariano, D. (1998). „Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis”. Biochemistry 37: 9305-9315. PMID 9649311.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.