Fosfometilpirimidinska sintaza
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| Fosfometilpirimidinska sintaza | |||||||||
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| Fosfometilpirimidinska sintaza dimer, Arabidopsis thaliana | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.99.17 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosfometilpirimidinska sintaza (EC 4.1.99.17, thiC (gen)) je enzim sa sistematskim imenom 5-amino-1-(5-fosfo-D-ribozil)imidazol format-lijaza (dekarboksilacija, formira 4-amino-2-metil-5-fosfometilpirimidin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-amino-1-(5-fosfo-D-ribozil)imidazol + S-adenozil-L-metionin
4-amino-2-metil-5-fosfometilpirimidin + 5'-dezoksiadenozin + L-metionin + format + CO
Ovaj enzim sadrži 4Fe-4S klaster.
Reference[uredi | uredi kod]
- ↑ Chatterjee, A., Li, Y., Zhang, Y., Grove, T.L., Lee, M., Krebs, C., Booker, S.J., Begley, T.P. and Ealick, S.E. (2008). „Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily”. Nat. Chem. Biol. 4: 758-765. PMID 18953358.
- ↑ Martinez-Gomez, N.C., Poyner, R.R., Mansoorabadi, S.O., Reed, G.H. and Downs, D.M. (2009). „Reaction of AdoMet with ThiC generates a backbone free radical”. Biochemistry 48: 217-219. PMID 19113839.
- ↑ Chatterjee, A., Hazra, A.B., Abdelwahed, S., Hilmey, D.G. and Begley, T.P. (2010). „A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase”. Angew. Chem. Int. Ed. Engl. 49: 8653-8656. PMID 20886485.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.