Fosfolipid-translocirajuća ATPaza

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Fosfolipid-translocirajuća ATPaza
Identifikatori
EC broj 3.6.3.1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Fosfolipid-translocirajuća ATPaza (EC 3.6.3.1, Mg2+-ATPaza, flipaza, aminofosfolipid-transportna ATPaza) je enzim sa sistematskim imenom ATP fosfohidrolaza (translokacija fosfolipida).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + H2O + fosfolipid [strana 1] ADP + fosfat + fosfolipid [strana 2]

Ova P-tip ATPaza podleže kovalentnoj fosforilaciji tokom transportnog ciklusa.

Reference[uredi - уреди | uredi izvor]

  1. Morris, M.B., Auland, M.E., Xu, Y.H. and Roufogalis, B.D. (1993). "Characterization of the Mg2+-ATPase activity of the human erythrocyte membrane". Biochem. Mol. Biol. Int. 31: 823–832. PMID 8136700. 
  2. Vermeulen, W.P., Briede, J.J. and Rolofsen, B. (1996). "Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity". Mol. Membr. Biol. 13: 95–102. PMID 8839453. 
  3. Suzuki, H., Kamakura, M., Morii, M. and Takeguchi, N. (1997). "The phospholipid flippase activity of gastric vesicles". J. Biol. Chem. 272: 10429–10434. PMID 9099684. 
  4. Auland, M.E., Roufogalis, B.D., Devaux, P.F. and Zachowski, A. (1994). "Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes". Proc. Natl. Acad. Sci. USA 91: 10938–10942. PMID 7971987. 
  5. Alder-Baerens, N., Lisman, Q., Luong, L., Pomorski, T. and Holthuis, J.C. (2006). "Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles". Mol. Biol. Cell 17: 1632–1642. PMID 16452632. 
  6. Lopez-Marques, R.L., Poulsen, L.R., Hanisch, S., Meffert, K., Buch-Pedersen, M.J., Jakobsen, M.K., Pomorski, T.G. and Palmgren, M.G. (2010). "Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA α-subunit". Mol. Biol. Cell 21: 791–801. PMID 20053675. 

Literatura[uredi - уреди | uredi izvor]

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