Fosfolipid-translocirajuća ATPaza
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Fosfolipid-translocirajuća ATPaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.6.3.1 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosfolipid-translocirajuća ATPaza (EC 3.6.3.1, Mg2+-ATPaza, flipaza, aminofosfolipid-transportna ATPaza) je enzim sa sistematskim imenom ATP fosfohidrolaza (translokacija fosfolipida).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + H2O + fosfolipid [strana 1] ADP + fosfat + fosfolipid [strana 2]
Ova P-tip ATPaza podleže kovalentnoj fosforilaciji tokom transportnog ciklusa.
Reference[uredi | uredi kod]
- ↑ Morris, M.B., Auland, M.E., Xu, Y.H. and Roufogalis, B.D. (1993). „Characterization of the Mg2+-ATPase activity of the human erythrocyte membrane”. Biochem. Mol. Biol. Int. 31: 823-832. PMID 8136700.
- ↑ Vermeulen, W.P., Briede, J.J. and Rolofsen, B. (1996). „Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity”. Mol. Membr. Biol. 13: 95-102. PMID 8839453.
- ↑ Suzuki, H., Kamakura, M., Morii, M. and Takeguchi, N. (1997). „The phospholipid flippase activity of gastric vesicles”. J. Biol. Chem. 272: 10429-10434. PMID 9099684.
- ↑ Auland, M.E., Roufogalis, B.D., Devaux, P.F. and Zachowski, A. (1994). „Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes”. Proc. Natl. Acad. Sci. USA 91: 10938-10942. PMID 7971987.
- ↑ Alder-Baerens, N., Lisman, Q., Luong, L., Pomorski, T. and Holthuis, J.C. (2006). „Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles”. Mol. Biol. Cell 17: 1632-1642. PMID 16452632.
- ↑ Lopez-Marques, R.L., Poulsen, L.R., Hanisch, S., Meffert, K., Buch-Pedersen, M.J., Jakobsen, M.K., Pomorski, T.G. and Palmgren, M.G. (2010). „Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA α-subunit”. Mol. Biol. Cell 21: 791-801. PMID 20053675.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.