Fosfatidatna fosfataza
(Preusmjereno sa stranice Fosfatidat fosfataza)
| Fosfatidatna fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.4 | ||||||||
| CAS broj | 9025-77-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfatidatna fosfataza (EC 3.1.3.4, fosfatno kiselinska fosfataza, kiselinska fosfatidilna fosfataza, fosfatno kiselinska fosfohidrolaza, PAP, Lipin) je enzim sa sistematskim imenom diacilglicerol-3-fosfat fosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1,2-diacilglicerol 3-fosfat + H2O 1,2-diacil-sn-glicerol + fosfat
Ovaj enzim katalizuje Mg2+-zavisnu defosforilaciju 1,2-diacilglicerol-3-fosfata.
Reference[uredi | uredi kod]
- ↑ Smith, S.W., Weiss, S.B. and Kennedy, E.P. (1957). „The enzymatic dephosphorylation of phosphatidic acids”. J. Biol. Chem. 228: 915-922. PMID 13475370.
- ↑ Carman, G.M. and Han, G.S. (2009). „Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis”. J. Biol. Chem. 284: 2593-2597. PMID 18812320.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.