Feredoksin:tioredoksin reduktaza
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| Feredoksin:tioredoksin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.7.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Feredoksin:tioredoksin reduktaza (EC 1.8.7.2, feredoksin:tioredoksin-reduktaza) je enzim sa sistematskim imenom feredoksin:tioredoksin disulfid oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- 2 redukovani feredoksin + tioredoksin disulfid 2 oksidovani feredoksin + tioredoksin + 2 H+
Ovaj enzim sadrži [4Fe-4S] klaster i disulfid. On formira mešoviti disulfid sa tioredoksinom na jednoj strani, dok je na drugoj strani mesto vezivanja feredoksina, što omogućava dva jednoelektronska transfera.
Reference[uredi | uredi kod]
- ↑ Buchanan, B.B. (1991). „Regulation of CO2 assimilation in oxygenic photosynthesis: the ferredoxin/thioredoxin system. Perspective on its discovery, present status, and future development”. Arch. Biochem. Biophys. 288: 1-9. PMID 1910303.
- ↑ Chow, L.P., Iwadate, H., Yano, K., Kamo, M., Tsugita, A., Gardet-Salvi, L., Stritt-Etter, A.L. and Schurmann, P. (1995). „Amino acid sequence of spinach ferredoxin:thioredoxin reductase catalytic subunit and identification of thiol groups constituting a redox-active disulfide and a [4Fe-4S] cluster”. Eur. J. Biochem. 231: 149-156. PMID 7628465.
- ↑ Staples, C.R., Ameyibor, E., Fu, W., Gardet-Salvi, L., Stritt-Etter, A.L., Schurmann, P., Knaff, D.B. and Johnson, M.K. (1996). „The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters”. Biochemistry 35: 11425-11434. PMID 8784198.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.