Koagulacioni faktor Xa

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Koagulacioni faktor Xa
Identifikatori
EC broj 3.4.21.6
CAS broj 2594078
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Koagulacioni faktor Xa (EC 3.4.21.6, trombokinaza, protrombaza, protrombinaza, aktivirani krvno-koagulacioni faktor X, autoprotrombinska C, tromboplastin, plazmični tromboplastin, faktor Xa, aktivirani Stjuart-Prauer faktor, aktivirani faktor X) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno razlaganje Arg-Thr i zatim Arg-Ile veza u protrombinu čime se formira trombin

Ovaj krvno koagulacioni faktor se formira iz proenzima faktor X putem ograničene proteolize.

Reference[uredi | uredi kod]

  1. Fujikawa, K. and Davie, E.W. (1976). „Bovine factor X (Stuart factor)”. Methods Enzymol. 45: 89-95. PMID 1012041. 
  2. Jesty, J. and Nemerson, Y. (1976). „The activation of bovine coagulation factor X”. Methods Enzymol. 45: 95-107. PMID 1012042. 
  3. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. (1979). „The role of serine proteases in the blood coagulation cascade”. Adv. Enzymol. 48: 277-318. PMID 367103. 
  4. Jackson, C.M. and Nemerson, Y. (1980). „Blood coagulation”. Annu. Rev. Biochem. 49: 765-811. PMID 6996572. 
  5. McMullen, B.A., Fujikawa, K., Kisiel, W., Sasagawa, T., Howald, W.N., Kwa, E.Y. and Weinstein, B. (1983). „Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as β-hydroxyaspartic acid”. Biochemistry 22: 2875-2884. PMID 6871167. 
  6. Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301. 

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