Endotelin konvertujući enzim 1
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| Endotelin konvertujući enzim 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.71 | ||||||||
| CAS broj | 138238-81-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Endotelin konvertujući enzim 1 (EC 3.4.24.71, endotelin-konvertujući enzim, ECE-1) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -Trp21-Val- veze u velikom endotelinu radi formiranja endotelina 1
Ova metaloendopeptidaza pripada familiji M13 (neprilizinskoj familiji).
Reference[uredi | uredi kod]
- ↑ Takahashi, M., Matsushita, Y., Iijima, Y. and Tanzawa, K. (1993). „Purification and characterization of endothelin-converting enzyme from rat lung”. J. Biol. Chem. 268: 21394-21398. PMID 8407980.
- ↑ Shimada, K., Takahashi, M. and Tanzawa, K. (1994). „Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells”. J. Biol. Chem. 269: 18275-18278. PMID 8034569.
- ↑ Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., DeWit, D. and Yanagisawa, M. (1994). „ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1”. Cell 78: 473-485. PMID 8062389.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.