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EC broj
CAS broj 91195-87-8
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MetaCyc metabolic pathway
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PDB structures

Endo-alfa-sijalidaza (EC, endo-N-acilneuraminidaza, endoneuraminidaza, endo-N-acetilneuraminidaza, poli(alfa-2,8-sijalozil) endo-N-acetilneuraminidaza, poli(alfa-2,8-sijalozid) alfa-2,8-sijalozilhidrolaza, endosijalidaza, endo-N) je enzim sa sistematskim imenom polisijalozid (2->8)-alfa-sijalozilhidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Endohidroliza (2->8)-alfa-sijalozil veza u oligo- ili poli(sijaliskoj) kiselini

Dejstvo ovog enzima je ograničeno na acetilisane supstrate.

Reference[uredi - уреди | uredi izvor]

  1. Finne, J., Mäkelä, P.H. (1985). "Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid". J. Biol. Chem. 260: 1265–1270. PMID 3968060. 
  2. Hallenbeck, P.C., Vimr, E.R., Yu, F., Bassler, B. and Troy, F.A. (1987). "Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-α-2,8-sialosyl carbohydrate units". J. Biol. Chem. 262: 3553–3561. PMID 3546309. 
  3. Kitakima, K., Inoue, S., Inoue, Y. and Troy, F.A. (1988). "Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies". J. Biol. Chem. 263: 18269–18276. PMID 3142874. 
  4. Kwiatkowski, B., Boscheck, B., Thicle, H. and Stirm, S. (1982). "Endo-N-acetylneuraminidase associated with bacteriophage particles". J. Virol. 43: 697–704. PMID 7109038. 
  5. Pelkonen, S., Pelkonen, J. and Finne, J. (1989). "Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins". J. Virol. 65: 4409–4416. PMID 2778882. 
  6. Tombinson, S. and Taylor, P.W. (1985). "Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide". J. Virol. 55: 374–378. PMID 3894684. 
  7. Cabezas, J.A. (1991). "Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase". Biochem. J. 278: 311–312. PMID 1883340. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]