Tubulinska GTPaza
(Preusmjereno sa stranice EC 3.6.5.6)
| Tubulinska GTPaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.5.6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tubulinska GTPaza (EC 3.6.5.6) je enzim sa sistematskim imenom GTP fosfohidrolaza (oslovađanje mikrotubule).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GTP + H2O GDP + fosfat
Ovaj enzim učestvuje u savijanju tubulina.
Reference[uredi | uredi kod]
- ↑ Yu, X.C. and Margolin, W. (1997). „Ca2+-mediated GTP-dependent dynamic assembly of bacetrial cell division protein FtsZ into asters and polymer networks in vitro”. EMBO J. 16: 5455-5463. PMID 9312004.
- ↑ Tian, G., Bhamidipati, A., Cowan, N.J. and Lewis, S.A. (1999). „Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the α/β-tubulin heterodimer”. J. Biol. Chem. 274: 24054-24058. PMID 10446175.
- ↑ Roychowdhury, S., Panda, D., Wilson, L. and Rasenick, M.M. (1999). „G protein α subunits activate tubulin GTPase and modulate microtubule polymerization dynamics”. J. Biol. Chem. 274: 13485-13490. PMID 10224115.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.