Endotiapepsin
(Preusmjereno sa stranice EC 3.4.23.22)
| Endotiapepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.22 | ||||||||
| CAS broj | 37205-60-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Endotiapepsin (EC 3.4.23.22, Endothia aspartinska proteinaza, Endothia kiselinska proteinaza, Endothia parasitica kiselinska proteinaza, Endothia parasitica aspartinsk proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa specifičnošću sličnom pepsinu A. Postoji preferencija za hidrofobne ostatake u P1 i P1'. Ne dolazi do razlaganja Ala14-Leu u B lancu insulina ili Z-Glu-Tyr. Dolazi do zgrušavanja mlaka
Ovaj enzim je prisutan u askomiceti Endothia parasitica.
Reference[uredi | uredi kod]
- ↑ Whitaker, J.R. (1970). „Protease of Endothia parasitica”. Methods Enzymol. 19: 436-445.
- ↑ Williams, D.C., Whitaker, J.R. and Caldwell, P.V. (1972). „Hydrolysis of peptide bonds of the oxidized B-chain of insulin by Endothia parasitica protease”. Arch. Biochem. Biophys. 149: 52-61. PMID 4552802.
- ↑ Barkholt, V. (1987). „Amino acid sequence of endothiapepsin. Complete primary structure of the aspartic protease from Endothia parasitica”. Eur. J. Biochem. 167: 327-338. PMID 3305016.
- ↑ Cooper, J., Foundling, S., Hemmings, A., Blundell, T., Jones, D.M., Hallett, A. and Szelke, M. (1987). „The structure of a synthetic pepsin inhibitor complexed with endothiapepsin”. Eur. J. Biochem. 169: 215-221. PMID 3119339.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.