Hijaluronoglukozaminidaza
(Preusmjereno sa stranice EC 3.2.1.35)
| Hijaluronoglukozaminidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.2.1.35 | ||||||||
| CAS broj | 37326-33-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hijaluronoglukozaminidaza (EC 3.2.1.35, hijaluronidaza, hijaluronoglukozidaza, hondroitinaza, hondroitinaza I) je enzim sa sistematskim imenom hijaluronat 4-glikanohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Randomna hidroliza (1->4)-veza između N-acetil-beta-D-glukozamina i D-glukuronatnih ostataka u hijaluronatu
Ovaj enzim takođe hidrolizuje 1,4-beta-D-glikozidne veze između N-acetil-galaktozamina ili N-acetilgalaktozamin sulfata i glukuronske kiseline u hondroitinu, hondroitin 4- i 6-sulfatima, i dermatanu.
Reference[uredi | uredi kod]
- ↑ Meyer, K., Hoffman, P. and Linker, A. (1960). „Hyaluronidases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 447-460.
- ↑ Rapport, M.M., Myer, K. and Linker, A. (1951). „Analysis of the products formed on hydrolysis of hyaluronic acid by testicular hyaluronidase”. J. Am. Chem. Soc. 73: 2416-2420.
- ↑ Weissmann, B. (1955). „The transglycosylative action of testicular hyaluronidase”. J. Biol. Chem. 216: 783-794. PMID 13271353.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Meyer, K., Hoffman, P. and Linker, A. (1960). „Hyaluronidases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 447-460.